The Formation Mechanism of Defects, Spiral Wave in the Network of Neurons

doi:10.1371/journal.pone.0055403

CORC > 兰州理工大学 > 兰州理工大学 > 理学院

	The Formation Mechanism of Defects, Spiral Wave in the Network of Neurons
	Wu, Xinyi; Ma, Jun
刊名	PLOS ONE
	2013-01-31
卷号	8 期号:1
ISSN号	1932-6203
DOI	10.1371/journal.pone.0055403
英文摘要	A regular network of neurons is constructed by using the Morris-Lecar (ML) neuron with the ion channels being considered, and the potential mechnism of the formation of a spiral wave is investigated in detail. Several spiral waves are initiated by blocking the target wave with artificial defects and/or partial blocking (poisoning) in ion channels. Furthermore, possible conditions for spiral wave formation and the effect of partial channel blocking are discussed completely. Our results are summarized as follows. 1) The emergence of a target wave depends on the transmembrane currents with diversity, which mapped from the external forcing current and this kind of diversity is associated with spatial heterogeneity in the media. 2) Distinct spiral wave could be induced to occupy the network when the target wave is broken by partially blocking the ion channels of a fraction of neurons (local poisoned area), and these generated spiral waves are similar with the spiral waves induced by artificial defects. It is confirmed that partial channel blocking of some neurons in the network could play a similar role in breaking a target wave as do artificial defects; 3) Channel noise and additive Gaussian white noise are also considered, and it is confirmed that spiral waves are also induced in the network in the presence of noise. According to the results mentioned above, we conclude that appropriate poisoning in ion channels of neurons in the network acts as 'defects' on the evolution of the spatiotemporal pattern, and accounts for the emergence of a spiral wave in the network of neurons. These results could be helpful to understand the potential cause of the formation and development of spiral waves in the cortex of a neuronal system.
资助项目	National Nature Science of Foundation of China[11265008]
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	PUBLIC LIBRARY SCIENCE
WOS记录号	WOS:000314610600099
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/34761]
专题	理学院
通讯作者	Ma, Jun
作者单位	Lanzhou Univ Technol, Dept Phys, Lanzhou, Peoples R China
推荐引用方式 GB/T 7714	Wu, Xinyi,Ma, Jun. The Formation Mechanism of Defects, Spiral Wave in the Network of Neurons[J]. PLOS ONE,2013,8(1).
APA	Wu, Xinyi,&Ma, Jun.(2013).The Formation Mechanism of Defects, Spiral Wave in the Network of Neurons.PLOS ONE,8(1).
MLA	Wu, Xinyi,et al."The Formation Mechanism of Defects, Spiral Wave in the Network of Neurons".PLOS ONE 8.1(2013).