A novel pyrazoline-based fluorescent probe for Cu2+in aqueous solution and imaging in live cell

doi:10.1016/j.inoche.2021.108612

CORC > 兰州理工大学 > 兰州理工大学 > 石油化工学院

	A novel pyrazoline-based fluorescent probe for Cu2+in aqueous solution and imaging in live cell
	Zhang, Ying-peng 1; Zhao, Yu-chen 1; Xue, Qing-hua 1; Yang, Yun-shang 1; Guo, Hui-Chen 2,3; Xue, Ji-Jun 4,5
刊名	INORGANIC CHEMISTRY COMMUNICATIONS
	2021-07
卷号	129
关键词	Pyrazoline Cu2+fluorescent probe Reversible recognition Cell imaging
ISSN号	1387-7003
DOI	10.1016/j.inoche.2021.108612
英文摘要	In this study, a new pyrazoline derivate (1-acetyl-3- (2-hydroxy-1-naphthyl)-5-(2-phenyl-2H-chromene)-2-pyrazoline, N) is described as fluorescent probe for fluorometric detection of Cu2+. This fluorescence of probe has a high selectivity only toward Cu2+ ion in the other metal ions. It is remarkably observed that the fluorescence intensity of N decreased in the presence of Cu2+ ions with a strong capability to resist perturbations. The Limit of detection (LOD) value is calculated as 8.85 x 10-7 M for Cu2+ while the complexation constant is calculated as 3.14 x 105 M-2 via fluorescence measurements. The interaction between of N and Cu2+ is reversible after adding PPi. The optimized calculation of the probe for Cu2+ is confirmed by TD-DFT calculations. N-Cu2 thorn is successfully applied in the intracellular imaging in living PK-21cells that will have a great chance for wide application.
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000658801000003
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/148995]
专题	石油化工学院
作者单位	1.Lanzhou Univ Technol, Sch Petrochem Engn, Lanzhou 730050, Peoples R China; 2.Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Lanzhou 730046, Peoples R China; 3.Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Natl Foot & Mouth Dis Reference Lab, Lanzhou 730046, Peoples R China; 4.Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; 5.Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ying-peng,Zhao, Yu-chen,Xue, Qing-hua,et al. A novel pyrazoline-based fluorescent probe for Cu2+in aqueous solution and imaging in live cell[J]. INORGANIC CHEMISTRY COMMUNICATIONS,2021,129.
APA	Zhang, Ying-peng,Zhao, Yu-chen,Xue, Qing-hua,Yang, Yun-shang,Guo, Hui-Chen,&Xue, Ji-Jun.(2021).A novel pyrazoline-based fluorescent probe for Cu2+in aqueous solution and imaging in live cell.INORGANIC CHEMISTRY COMMUNICATIONS,129.
MLA	Zhang, Ying-peng,et al."A novel pyrazoline-based fluorescent probe for Cu2+in aqueous solution and imaging in live cell".INORGANIC CHEMISTRY COMMUNICATIONS 129(2021).