A new approach for membrane modification based on electrochemically mediated living polymerization and self-assembly of N-tert-butyl amide- and β-cyclodextrin-involved macromolecules for blood purification

doi:10.1016/j.msec.2018.10.075

CORC > 兰州理工大学 > 兰州理工大学 > 省部共建有色金属先进加工与再利用国家重点实验室

	A new approach for membrane modification based on electrochemically mediated living polymerization and self-assembly of N-tert-butyl amide- and β-cyclodextrin-involved macromolecules for blood purification
	Ran, Fen 1,2; Wu, Jiayu 2; Niu, Xiaoqin 4; Li, Dan 2; Nie, Chuanxiong 3; Wang, Rui 3; Zhao, Weifeng 3; Zhang, Weijie 5; Chen, Yuhong 4; Zhao, Changsheng 3
刊名	Materials Science and Engineering C
	2019-02-01
卷号	95 页码:122-133
关键词	Amides Biocompatibility Chemical activation Contact angle Cyclodextrins Enzymes Macromolecules Membranes Platelets Purification Self assembly Surface treatment Activated partial thromboplastin time Blood compatibility Complement activations Heparin-like Modification of polymers Polyethersulfone membrane Polymer membrane Polymerization conditions
ISSN号	09284931
DOI	10.1016/j.msec.2018.10.075
英文摘要	We report a convenient, highly efficient, and universal approach for blood-compatible modification of polymer membrane based on the SI-eATRP, RAFT, and self-assembly of N-tert-butyl amide and β-cyclodextrin existed in macromolecules chains. The functional membrane surfaces with any polymer chains of hydrophilic, ionic polymer, and polysaccharide segments, for example, the copolymers of N-vinyl pyrrolidone, sodium p-styrenesulfonate hydrate, and glucose allyl amide, are easily designed and fabricated; and the thickness of polymer brushes are efficiently controlled by polymerization conditions like monomer concentration and initiator amount. As a key bio-plastic, the modified polyethersulfone membrane shows suppressed platelet adhesion, significant decreases in thrombin-antithrombin generation, and the complement activations on C3a and C5a levels compared with pristine polyethersulfone membrane; while the platelet activation (PF4) decreased. Due to the similar groups as heparin-like structure, the modified membrane effectively prolonged the activated partial thromboplastin time, thrombin time, and prothrombin time. The water contact angle of the modified membrane decreases from 89.2 to 22.3° and the cytocompatibility of the modified membranes largely enhanced. It could be concluded that the new approach could be widely used for polymer membrane modification, and the mimic heparin-like surface seems to be a promising structure to improve the biocompatibility for blood purification application. © 2018 Elsevier B.V.
资助项目	State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals[18LHPY002]
WOS研究方向	Materials Science
语种	英语
出版者	Elsevier Ltd
WOS记录号	WOS:000455858300014
状态	已发表
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/114388]
专题	省部共建有色金属先进加工与再利用国家重点实验室材料科学与工程学院石油化工学院生命科学与工程学院
通讯作者	Ran, Fen; Zhao, Changsheng
作者单位	1.Lanzhou Univ Technol, State Key Lab Adv Proc & Recycling Nonferrous Met, Lanzhou 730050, Gansu, Peoples R China 2.Lanzhou Univ Technol, Sch Mat Sci & Engn, Lanzhou 730050, Gansu, Peoples R China 3.Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Sichuan, Peoples R China 4.Lanzhou Univ Technol, Coll Petrochem Technol, Lanzhou 730050, Gansu, Peoples R China 5.Lanzhou Univ Technol, Coll Life Sci & Engn, Lanzhou 730050, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Ran, Fen,Wu, Jiayu,Niu, Xiaoqin,et al. A new approach for membrane modification based on electrochemically mediated living polymerization and self-assembly of N-tert-butyl amide- and β-cyclodextrin-involved macromolecules for blood purification[J]. Materials Science and Engineering C,2019,95:122-133.
APA	Ran, Fen.,Wu, Jiayu.,Niu, Xiaoqin.,Li, Dan.,Nie, Chuanxiong.,...&Zhao, Changsheng.(2019).A new approach for membrane modification based on electrochemically mediated living polymerization and self-assembly of N-tert-butyl amide- and β-cyclodextrin-involved macromolecules for blood purification.Materials Science and Engineering C,95,122-133.
MLA	Ran, Fen,et al."A new approach for membrane modification based on electrochemically mediated living polymerization and self-assembly of N-tert-butyl amide- and β-cyclodextrin-involved macromolecules for blood purification".Materials Science and Engineering C 95(2019):122-133.