Fabrication and cytocompatibility evaluation for blood-compatible polyethersulfone membrane modified by a synthesized poly (vinyl pyrrolidone)-block-poly (acrylate-graft-poly(methyl methacrylate))-block-poly-(vinyl pyrrolidone)

doi:10.1002/pat.3718

	Fabrication and cytocompatibility evaluation for blood-compatible polyethersulfone membrane modified by a synthesized poly (vinyl pyrrolidone)-block-poly (acrylate-graft-poly(methyl methacrylate))-block-poly-(vinyl pyrrolidone)
	Ran, Fen 1,2; Song, Haiming 2; Ma, Lang 3; Niu, Xiaoqin 1; Wu, Jiayu 2; Zhang, Weijie 4; Kang, Long 2; Zhao, Changsheng 3
刊名	POLYMERS FOR ADVANCED TECHNOLOGIES
	2016-05
卷号	27 期号:5 页码:591-596
关键词	polyethersulfone membrane cytocompatibility surface modification
ISSN号	1042-7147
DOI	10.1002/pat.3718
英文摘要	Polyethersulfone (PES) membrane, one of the most important polymeric materials because of its good chemical resistance, thermal stability, mechanical, and film-forming properties, has already been used in hemodialysis, tissue engineering, and artificial organs. In order to improve the blood compatibility of PES membrane, many amphiphilic block copolymers have been synthesized and used as additives for surface modification. The object of this study is to develop a hydrophilic PES membrane by blending a comblike amphiphilic block copolymer poly (vinyl pyrrolidone)-block-poly [acrylate-graft-poly (methyl methacrylate)]-block-poly-(vinyl pyrrolidone) [PVP-b-P (AE-g-PMMA)-b-PVP] synthesized by RAFT polymerization. The cytocompatibility performance of PVP-b-P (AE-g-PMMA)-b-PVP modified PES membrane was evaluated, which showed better cytocompatibility compared with that of pristine PES membrane. Endothelial cells cultured on the modified membranes present improved growth in terms of scanning electron microscope observation, MTT assay, and confocal laser scanning microscope observation. These results indicate that the modified membrane has great potential application in blood-contact fields such as hemodialysis and bio-artificial liver supports. Copyright (c) 2015 John Wiley & Sons, Ltd.
资助项目	University Scientific Research Project of Gansu Province[2014B-025]
WOS研究方向	Polymer Science
语种	英语
出版者	WILEY
WOS记录号	WOS:000373924200003
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/33713]
专题	材料科学与工程学院生命科学与工程学院
通讯作者	Ran, Fen; Zhao, Changsheng
作者单位	1.Univ Calif Santa Cruz, Dept Chem & Biochem, 1156 High St, Santa Cruz, CA 95064 USA 2.Lanzhou Univ Technol, Sch Mat Sci & Engn, State Key Lab Gansu Adv Nonferrous Met Mat, Lanzhou 730050, Peoples R China 3.Sichuan Univ, Coll Polymer Sci & Engn, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China 4.Lanzhou Univ Technol, Coll Life Sci & Engn, Lanzhou 730050, Peoples R China
推荐引用方式 GB/T 7714	Ran, Fen,Song, Haiming,Ma, Lang,et al. Fabrication and cytocompatibility evaluation for blood-compatible polyethersulfone membrane modified by a synthesized poly (vinyl pyrrolidone)-block-poly (acrylate-graft-poly(methyl methacrylate))-block-poly-(vinyl pyrrolidone)[J]. POLYMERS FOR ADVANCED TECHNOLOGIES,2016,27(5):591-596.
APA	Ran, Fen.,Song, Haiming.,Ma, Lang.,Niu, Xiaoqin.,Wu, Jiayu.,...&Zhao, Changsheng.(2016).Fabrication and cytocompatibility evaluation for blood-compatible polyethersulfone membrane modified by a synthesized poly (vinyl pyrrolidone)-block-poly (acrylate-graft-poly(methyl methacrylate))-block-poly-(vinyl pyrrolidone).POLYMERS FOR ADVANCED TECHNOLOGIES,27(5),591-596.
MLA	Ran, Fen,et al."Fabrication and cytocompatibility evaluation for blood-compatible polyethersulfone membrane modified by a synthesized poly (vinyl pyrrolidone)-block-poly (acrylate-graft-poly(methyl methacrylate))-block-poly-(vinyl pyrrolidone)".POLYMERS FOR ADVANCED TECHNOLOGIES 27.5(2016):591-596.