In vitro studies on the application of colloidal emulsion aphrons to drug overdose treatment

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	In vitro studies on the application of colloidal emulsion aphrons to drug overdose treatment
	Dai, YJ ; Deng, T ; Lu, FP
刊名	INTERNATIONAL JOURNAL OF PHARMACEUTICS
	2006-03-27
卷号	311 期号:1-2 页码:165-171
关键词	colloidal emulsion aphron detoxification drug overdose extraction
ISSN号	0378-5173
其他题名	Int. J. Pharm.
中文摘要	Colloidal emulsion aphrons (CEAs) are considered as the micron-sized water-in-oil (W/O) emulsion-cores encapsulated by a '' soapy shell '' consisting of multi-layer surfactant molecules. In this dispersion, the emulsion-core sizes are mainly in 10-100 mu m and that of the inner phase droplets are in 1-5 mu m. CEAs not only behave analogously to emulsion liquid membrane (ELM) in extraction with advantages of high concentration ratio, counter-concentration extraction and combination of extraction with backwash together, but also have the large interface areas, easy scatteration and quick extraction which colloidal liquid aphrons (CLAs) possess. CEA extraction overcomes the restriction of partition equilibrium between the water and the oil phase that CLAs have. They have greater extraction capacity than CLAs. In this study, the application of CEAs to drug overdose treatment was studied using salicylic acid as the model drug, paraffin oil as the membrane phase, PEG-30 dipolyhydroxystearate (PI35) as the hydrophobic surfactant, nonylphenol ethoxylate-10 (NP10) as the hydrophilic surfactant and NaOH solution as the receptor phase. Also some factors affecting the stability of this dispersion and extraction ratio were investigated. In order to prepare CEAs successfully, the concentrations of NP10 and PI35 should be in 1.5-3.0% (w/v) and 0.25-1.0% (w/v), respectively, together with the ratio of the Volume of oil phase to the volume of inner aqueous phase of CEAs, R-oi >= 1:1. For the extraction of salicylic acid, the pH value of the feed phase was Supposed to be lower than 2.0 and the suitable NaOH concentration of the receptor phase was higher than 0.02 mol/L. Under this condition, more than 98.7% of salicylic acid was transported into receptor phase in half a minute. (c) 2006 Elsevier B.V. All rights reserved.
英文摘要	Colloidal emulsion aphrons (CEAs) are considered as the micron-sized water-in-oil (W/O) emulsion-cores encapsulated by a '' soapy shell '' consisting of multi-layer surfactant molecules. In this dispersion, the emulsion-core sizes are mainly in 10-100 mu m and that of the inner phase droplets are in 1-5 mu m. CEAs not only behave analogously to emulsion liquid membrane (ELM) in extraction with advantages of high concentration ratio, counter-concentration extraction and combination of extraction with backwash together, but also have the large interface areas, easy scatteration and quick extraction which colloidal liquid aphrons (CLAs) possess. CEA extraction overcomes the restriction of partition equilibrium between the water and the oil phase that CLAs have. They have greater extraction capacity than CLAs. In this study, the application of CEAs to drug overdose treatment was studied using salicylic acid as the model drug, paraffin oil as the membrane phase, PEG-30 dipolyhydroxystearate (PI35) as the hydrophobic surfactant, nonylphenol ethoxylate-10 (NP10) as the hydrophilic surfactant and NaOH solution as the receptor phase. Also some factors affecting the stability of this dispersion and extraction ratio were investigated. In order to prepare CEAs successfully, the concentrations of NP10 and PI35 should be in 1.5-3.0% (w/v) and 0.25-1.0% (w/v), respectively, together with the ratio of the Volume of oil phase to the volume of inner aqueous phase of CEAs, R-oi >= 1:1. For the extraction of salicylic acid, the pH value of the feed phase was Supposed to be lower than 2.0 and the suitable NaOH concentration of the receptor phase was higher than 0.02 mol/L. Under this condition, more than 98.7% of salicylic acid was transported into receptor phase in half a minute. (c) 2006 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	LIQUID MEMBRANES ; SALICYLIC-ACID ; SUICIDE
收录类别	SCI
原文出处	://WOS:000236526600022
语种	英语
WOS记录号	WOS:000236526600022
公开日期	2013-10-24
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.ipe.ac.cn/handle/122111/3997]
专题	过程工程研究所_研究所（批量导入）
作者单位	1.Tianjin Univ Sci & Technol, Coll Biotechnol, Tianjin Key Lab Ind Microbiol, Tianjin 300222, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Dai, YJ,Deng, T,Lu, FP. In vitro studies on the application of colloidal emulsion aphrons to drug overdose treatment[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2006,311(1-2):165-171.
APA	Dai, YJ,Deng, T,&Lu, FP.(2006).In vitro studies on the application of colloidal emulsion aphrons to drug overdose treatment.INTERNATIONAL JOURNAL OF PHARMACEUTICS,311(1-2),165-171.
MLA	Dai, YJ,et al."In vitro studies on the application of colloidal emulsion aphrons to drug overdose treatment".INTERNATIONAL JOURNAL OF PHARMACEUTICS 311.1-2(2006):165-171.