Neuroprotective effects of cryptotanshinone and 1,2-dihydrotanshinone I against MPTP induced mouse model of Parkinson's disease

doi:10.1016/j.phytol.2018.05.016

CORC > 兰州理工大学 > 兰州理工大学

	Neuroprotective effects of cryptotanshinone and 1,2-dihydrotanshinone I against MPTP induced mouse model of Parkinson's disease
	Cao, Gui-yun 1,2,3; Wang, Xiao-hong 1,2,3; Li, Ke-ke 4; Zhao, Ai-hong 5; Shen, Li 3; Yu, Duo-nan 1,2,3
刊名	PHYTOCHEMISTRY LETTERS
	2018-08
卷号	26 页码:68-73
关键词	Parkinson's disease 1,2-dihydrotanshinone I Cryptotanshinone Neuroprotective effect Antioxidant
ISSN号	1874-3900
DOI	10.1016/j.phytol.2018.05.016
英文摘要	1,2-dihydrotanshinone I (DTs1) and cryptotanshinone (CTs) are the two major compounds isolated from Salvia castanea f. tomentosa Stib., which possess diverse biological effects such as antioxidant, anticancer, antiatherogenic, anti-hepatic fibrosis. However, there is no any report available on the neuroprotective effects of DTs1 and CTs against MPTP induced dopaminergic neurons damage. Therefore, in this study, we investigated the neuroprotective effects of DTs1 and CTs in the MPTP-induced PD model of C57BL/6 mice. Locomotor behavior, tyrosine hydroxylase (TH) protein expression indicated that DTs1 and CTs significantly improved TH expression, inhibited dopaminergic cell loss induced by MPTP. Biochemical parameters determination and realtime polymerase chain reaction (PCR) analysis revealed that DTs1 and CTs increased the activities and mRNA expressions of Superoxide Dismutase (SOD), Glutathione peroxidase (GSH-Px), Catalase (CAT), deceased the level of Malondialdehyde (MDA). These findings indicated that DTs1 and CTs showed neuroprotective effects in MPTP-induced PD mice, which might be associated with their antioxidant properties.
资助项目	National Natural Science Foundation of China[81603272]
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000438977200015
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/32548]
专题	兰州理工大学
通讯作者	Cao, Gui-yun
作者单位	1.Yangzhou Univ, Med Dept, Jiangsu Key Lab Expt & Translat Noncoding RNA Res, Yangzhou 225001, Jiangsu, Peoples R China 2.Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225001, Jiangsu, Peoples R China 3.Jiangsu Key Lab Integrated Tradit Chinese & Weste, Yangzhou 225001, Jiangsu, Peoples R China 4.Dalian Univ, Med Dept, Dalian 116622, Peoples R China 5.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Cao, Gui-yun,Wang, Xiao-hong,Li, Ke-ke,et al. Neuroprotective effects of cryptotanshinone and 1,2-dihydrotanshinone I against MPTP induced mouse model of Parkinson's disease[J]. PHYTOCHEMISTRY LETTERS,2018,26:68-73.
APA	Cao, Gui-yun,Wang, Xiao-hong,Li, Ke-ke,Zhao, Ai-hong,Shen, Li,&Yu, Duo-nan.(2018).Neuroprotective effects of cryptotanshinone and 1,2-dihydrotanshinone I against MPTP induced mouse model of Parkinson's disease.PHYTOCHEMISTRY LETTERS,26,68-73.
MLA	Cao, Gui-yun,et al."Neuroprotective effects of cryptotanshinone and 1,2-dihydrotanshinone I against MPTP induced mouse model of Parkinson's disease".PHYTOCHEMISTRY LETTERS 26(2018):68-73.