Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function

doi:10.1007/s40195-022-01435-1

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	Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function
	Yan, Yangyang 3,4; Li, Na 2; Guo, Feng 3,4; Wu, Anhua 1; Jin, Wei 3,4; Yang, Rui 3,4; Bai, Yun 3,4; Zhang, Xing 3,4
刊名	ACTA METALLURGICA SINICA-ENGLISH LETTERS
	2022-07-03
页码	13
关键词	Nitinol stents Conformability Radial force Endothelialization Intracranial stenosis treatment
ISSN号	1006-7191
DOI	10.1007/s40195-022-01435-1
通讯作者	Bai, Yun(ybai@imr.ac.cn) ; Zhang, Xing(xingzhang@imr.ac.cn)
英文摘要	Intracranial vascular stenting has been widely used for ischemic stroke. However, there are complication risks with stent implantation, such as poor wall apposition, stent migration, thromboembolism and stent restenosis, due to the mismatched radial force and conformability of the stents. Therefore, a novel intracranial vascular nitinol stent was fabricated in order to improve mechanical property and endothelialization function. The bending moment of the stents was calculated to be 0.346 N mm, which shows improved conformability. The radial force of the stents evaluated by the flat plate test was 0.0112 N/mm, within the range of the commercially available stent force (0.0065-0.0116 N/mm). Furthermore, the Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide derived from laminin was grafted onto the stent surfaces to promote endothelialization on vascular stents evaluated by the proliferation, adhesion and migration of human umbilical vein endothelial cells in vitro. The nitinol stents with improved mechanical property and endothelialization function are expected to reduce the recurrence risk of ischemic stroke after implantation.
资助项目	National Key Research and Development program[2018YFC1105503]
WOS研究方向	Metallurgy & Metallurgical Engineering
语种	英语
出版者	CHINESE ACAD SCIENCES, INST METAL RESEARCH
WOS记录号	WOS:000820119600001
资助机构	National Key Research and Development program
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/174889]
专题	金属研究所_中国科学院金属研究所
通讯作者	Bai, Yun; Zhang, Xing
作者单位	1.China Med Univ, Dept Neurosurg, Affiliated Hosp 1, Shenyang 110001, Peoples R China 2.Shenyang Univ, Coll Life Sci & Engn, Shenyang 110044, Peoples R China 3.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 4.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Yan, Yangyang,Li, Na,Guo, Feng,et al. Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function[J]. ACTA METALLURGICA SINICA-ENGLISH LETTERS,2022:13.
APA	Yan, Yangyang.,Li, Na.,Guo, Feng.,Wu, Anhua.,Jin, Wei.,...&Zhang, Xing.(2022).Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function.ACTA METALLURGICA SINICA-ENGLISH LETTERS,13.
MLA	Yan, Yangyang,et al."Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function".ACTA METALLURGICA SINICA-ENGLISH LETTERS (2022):13.