A Degradable and Osteogenic Mg-Based MAO-MT-PLGA Drug/Ion Delivery System for Treating an Osteoporotic Fracture

doi:10.3390/pharmaceutics14071481

CORC > 金属研究所 > 中国科学院金属研究所

	A Degradable and Osteogenic Mg-Based MAO-MT-PLGA Drug/Ion Delivery System for Treating an Osteoporotic Fracture
	Liu, Changxin 2,3; Zhang, Wen 2,3; Gao, Ming 2; Yang, Ke 2; Tan, Lili 2; Zhao, Wei 1
刊名	PHARMACEUTICS
	2022-07-01
卷号	14 期号:7 页码:21
关键词	animal experimental biocompatibility degradation performance magnesium alloy melatonin osteoporotic fracture
DOI	10.3390/pharmaceutics14071481
通讯作者	Tan, Lili(lltan@imr.ac.cn) ; Zhao, Wei(wzhao89@cmu.edu.cn)
英文摘要	Osteoporotic fractures are a very common bone disease that is difficult to completely cure. A large number of people worldwide suffer from pain caused by osteoporotic fractures every year, which can even cause disability and death. The compromised skeletal strength, lower density, trabecular microstructure, and bone-forming ability caused by osteoporotic fractures make them difficult to treat relative to normal fractures. An ideal scheme for osteoporotic fractures is to select internal fixation materials with matched mechanical and biological properties and carry anti-osteoporosis drugs on the plant to achieve bio-fixation and improve the condition of osteoporosis simultaneously. We designed a Mg-based MAO-MT-PLGA drug/ion delivery system (DDS) compatible with bone-like mechanical properties, degradation properties, and drug therapy. In this research, we evaluated the degradation behavior of Mg-based MAO-MT-PLGA DDS using immersion tests and electrochemical tests aided by SEM, EDS, XPS, XRD, and FT-IR. The DDS showed better corrosion resistance over Mg alloy and could release more Mg2+ due to the degradation of PLGA. According to cell viability and cell adhesion, the DDS showed better osteogenic characteristics over control group I (Mg alloy) and control group II (Mg-based MAO alloy), especially in the cells co-cultured with the leaching solution for 72 h, in which the DDS group increased to about 15% cell viability compared with group I (p < 0.05). The mRNA relative expressions, including ALP, collagen I, OCN, OPG, and Runx-2, as well as extracellular matrix calcium deposits of the DDS, are 1.5--2 times over control group I and control group II (p < 0.05), demonstrating a better ability to promote bone formation and inhibit bone resorption. After the DDS was implanted into the castrated rat model for one month, the trabeculae in the treatment group were significantly denser and stronger than those in the control group, with a difference of about 1.5 times in bone volume fraction, bone density, and the number of trabeculae, as well as the magnesium content in the bone tissue (p < 0.05). The above results demonstrated that the Mg-based MAO-MT-PLGA drug/ion delivery system is a potential treatment for osteoporotic fractures.
资助项目	National Key Research and Development Program of China[2020YFC1107501] ; National Natural Science Foundation of China[51971222] ; National Natural Science Foundation of China[51801220] ; Natural Science Foundation of Liaoning Province of China[2020-MS-001] ; Natural Science Foundation of Liaoning Province of China[2021-BS118] ; Natural Science Foundation of Shandong Province of China[ZR2021MH166] ; DongGuan Innovative Research Team Program[2020607134012] ; DongGuan Science and Technology Service Network Initiative[20201600200042]
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	MDPI
WOS记录号	WOS:000833228000001
资助机构	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province of China ; Natural Science Foundation of Shandong Province of China ; DongGuan Innovative Research Team Program ; DongGuan Science and Technology Service Network Initiative
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/174756]
专题	金属研究所_中国科学院金属研究所
通讯作者	Tan, Lili; Zhao, Wei
作者单位	1.China Med Univ, Dept Orthoped, Hosp 4, 77 Puhe Rd, Shenyang 110122, Peoples R China 2.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China 3.Univ Sci & Technol China, Sch Mat Sci & Engn, 72 Wenhua Rd, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Liu, Changxin,Zhang, Wen,Gao, Ming,et al. A Degradable and Osteogenic Mg-Based MAO-MT-PLGA Drug/Ion Delivery System for Treating an Osteoporotic Fracture[J]. PHARMACEUTICS,2022,14(7):21.
APA	Liu, Changxin,Zhang, Wen,Gao, Ming,Yang, Ke,Tan, Lili,&Zhao, Wei.(2022).A Degradable and Osteogenic Mg-Based MAO-MT-PLGA Drug/Ion Delivery System for Treating an Osteoporotic Fracture.PHARMACEUTICS,14(7),21.
MLA	Liu, Changxin,et al."A Degradable and Osteogenic Mg-Based MAO-MT-PLGA Drug/Ion Delivery System for Treating an Osteoporotic Fracture".PHARMACEUTICS 14.7(2022):21.