An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors

doi:10.1093/molbev/msv058

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	An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors
	Jin, Jinpu ; He, Kun 1; Tang, Xing ; Li, Zhe 3; Lv, Le 1; Zhao, Yi ; Luo, Jingchu ; Gao, Ge
刊名	MOLECULAR BIOLOGY AND EVOLUTION
	2015
卷号	32 期号:7 页码:1767-1773
关键词	transcription factor transcriptional regulation network structure novel family wiring preference
ISSN号	0737-4038
DOI	10.1093/molbev/msv058
文献子类	Article
英文摘要	Transcription factors (TFs) play key roles in both development and stress responses. By integrating into and rewiring original systems, novel TFs contribute significantly to the evolution of transcriptional regulatory networks. Here, we report a high-confidence transcriptional regulatory map covering 388 TFs from 47 families in Arabidopsis. Systematic analysis of this map revealed the architectural heterogeneity of developmental and stress response subnetworks and identified three types of novel network motifs that are absent from unicellular organisms and essential for multicellular development. Moreover, TFs of novel families that emerged during plant landing present higher binding specificities and are preferentially wired into developmental processes and these novel network motifs. Further unveiled connection between the binding specificity and wiring preference of TFs explains the wiring preferences of novel-family TFs. These results reveal distinct functional and evolutionary features of novel TFs, suggesting a plausible mechanism for their contribution to the evolution of multicellular organisms.
学科主题	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
电子版国际标准刊号	1537-1719
出版地	OXFORD
WOS关键词	FLORAL HOMEOTIC GENES ; NETWORK MOTIFS ; ESCHERICHIA-COLI ; GENOMIC ANALYSIS ; FACTOR-BINDING ; DYNAMICS ; ARCHITECTURE ; PLANT ; BACTERIA ; CIRCUITS
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000360585900009
资助机构	National Natural Science Foundation of China [31470330] ; China 863 Programs [2006AA02Z334] ; State Key Laboratory of Protein and Plant Gene Research ; National Program for Support of Top-notch Young Professionals ; China Postdoctoral Science Foundation [2014M560017]
内容类型	期刊论文
源URL	[http://ir.ibcas.ac.cn/handle/2S10CLM1/25666]
专题	系统与进化植物学国家重点实验室
作者单位	1.Peking Univ, Ctr Bioinformat, Coll Life Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Bot, State Key Lab Systemat & Evolutionary Bot, Beijing, Peoples R China 3.Monsanto Biotechnol R&D Ctr, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Jin, Jinpu,He, Kun,Tang, Xing,et al. An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors[J]. MOLECULAR BIOLOGY AND EVOLUTION,2015,32(7):1767-1773.
APA	Jin, Jinpu.,He, Kun.,Tang, Xing.,Li, Zhe.,Lv, Le.,...&Gao, Ge.(2015).An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.MOLECULAR BIOLOGY AND EVOLUTION,32(7),1767-1773.
MLA	Jin, Jinpu,et al."An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors".MOLECULAR BIOLOGY AND EVOLUTION 32.7(2015):1767-1773.