Biodegradable Mg-based alloys: biological implications and restorative opportunities

doi:10.1080/09506608.2022.2079367

CORC > 金属研究所 > 中国科学院金属研究所

	Biodegradable Mg-based alloys: biological implications and restorative opportunities
	Lin, Xiao 8; Saijilafu 8; Wu, Xiexing 8; Wu, Kang 8; Chen, Jianquan 8; Tan, Lili 7; Witte, Frank 5,6; Yang, Huilin 8; Mantovani, Diego 3,4; Zhou, Huan 2
刊名	INTERNATIONAL MATERIALS REVIEWS
	2022-06-16
页码	39
关键词	Biodegradability Mg-based alloys biomaterials orthopedics stent biological properties tissue engineering translational medicine
ISSN号	0950-6608
DOI	10.1080/09506608.2022.2079367
通讯作者	Yang, Ke(kyang@imr.ac.cn) ; Yang, Lei(ylei@hebut.edu.cn)
英文摘要	Mg-based alloys as revolutionary implantable biomaterials have increasingly attracted considerable attention, owing to their biodegradability in vivo and beneficial effects on biological systems. The degradation process and products of Mg-based alloys have been reported to exhibit significant biological effects on host-tissue responses. However, these effects have not yet been fully understood. This review systemically summarizes and analyses the current understandings and recent research progress in this area. The primary focal points are the biological effects and related mechanisms associated with the degradation behaviour of Mg-based alloys. The biological impacts of the degradation products are elucidated and the arguable or controversial issues are also discussed, providing a pathway toward a greater understanding of the biological implications of Mg-based alloys. Furthermore, based on these biological implications, the restorative potential of Mg-based alloys for applications in tissue repair and regeneration is summarized. Finally, outlooks on biosafety evaluation and design strategies for Mg-based alloy implants are briefly discussed.
资助项目	National Key Researchand Development Program of China[2020YFC1107401] ; National Natural Science Foundation of China[82025025] ; National Natural Science Foundation of China[32171321] ; Suzhou Science and Technology Project[SYS2019022] ; China Postdoctoral Science Foundation[2020T130459] ; Full-time Talents Program of Hebei Province of China[2020HBQZYC012] ; Jiangsu Innovation and Entrepreneurship Program ; Priority Academic Program Development of Jiangsu High Education Institutions (PAPD) ; Academician Expert Workstation of Yunnan Province of China[202205AF150025] ; Innovation Fund of National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation of China[2021-NCRC-CXJJ-ZH-17]
WOS研究方向	Materials Science
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000812128400001
资助机构	National Key Researchand Development Program of China ; National Natural Science Foundation of China ; Suzhou Science and Technology Project ; China Postdoctoral Science Foundation ; Full-time Talents Program of Hebei Province of China ; Jiangsu Innovation and Entrepreneurship Program ; Priority Academic Program Development of Jiangsu High Education Institutions (PAPD) ; Academician Expert Workstation of Yunnan Province of China ; Innovation Fund of National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation of China
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/174383]
专题	金属研究所_中国科学院金属研究所
通讯作者	Yang, Ke; Yang, Lei
作者单位	1.Tianjin Univ, Tianjin Hosp, Dept Spine Surg, Tianjin, Peoples R China 2.Hebei Univ Technol, Ctr Hlth Sci & Engn CHSE, Sch Hlth Sci & Biomed Engn, Tianjin 300130, Peoples R China 3.Laval Univ, CHU Quebec Res Ctr, Quebec City, PQ, Canada 4.Laval Univ, Lab Biomat & Bioengn, CRC I, Dept Min Met Mat Engn, Quebec City, PQ, Canada 5.Charite Univ Med Berlin, Ctr Musculoskeletal Surg, Berlin Brandenburg Ctr Regenerat Therapies, Berlin, Germany 6.Charite Univ Med Berlin, Julius Wolff Inst, Berlin Brandenburg Ctr Regenerat Therapies, Berlin, Germany 7.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 8.Soochow Univ, Orthoped Inst, Affiliated Hosp 1, Dept Orthoped, Suzhou, Peoples R China
推荐引用方式 GB/T 7714	Lin, Xiao,Saijilafu,Wu, Xiexing,et al. Biodegradable Mg-based alloys: biological implications and restorative opportunities[J]. INTERNATIONAL MATERIALS REVIEWS,2022:39.
APA	Lin, Xiao.,Saijilafu.,Wu, Xiexing.,Wu, Kang.,Chen, Jianquan.,...&Yang, Lei.(2022).Biodegradable Mg-based alloys: biological implications and restorative opportunities.INTERNATIONAL MATERIALS REVIEWS,39.
MLA	Lin, Xiao,et al."Biodegradable Mg-based alloys: biological implications and restorative opportunities".INTERNATIONAL MATERIALS REVIEWS (2022):39.