<p>In silico insights into the receptor-mediated endocytosis of virus-like nanoparticles</p>

doi:10.1016/j.cplett.2022.139360

CORC > 海洋研究所 > 中国科学院海洋研究所 > 海洋腐蚀与防护研究发展中心

	In silico insights into the receptor-mediated endocytosis of virus-like nanoparticles
	Li, Zhen 1; Wei, Qi 1; Qi, Ziqiang 1; Zhou, Lixia 3; Li, Jiawei 1,2
刊名	CHEMICAL PHYSICS LETTERS
	2022-03-01
卷号	790 页码:7
关键词	Dissipative particle dynamics Bio-nano interaction Membrane remodeling Transmembrane transport Nanoparticle surface topology
ISSN号	0009-2614
DOI	10.1016/j.cplett.2022.139360
通讯作者	Li, Jiawei(xiicarson@gmail.com)
英文摘要	To provide insights into the receptor-mediated endocytosis of virus-like nanoparticles (VLPs), we carried out a series of in silico dissipative particle dynamics (DPD) simulations on the interaction of lipid membrane and VLPs with varying spike length and spike number. Of great interest is that the VLP endocytosis is facilitated by short spikes but hindered by long spikes, showing a "biphasic effect ". With scrutinizing the endocytosis pathway and dynamic behavior of receptors, we clarified molecular mechanisms underlying the biphasic effect. These results demonstrate the importance of nanotopography on cellular internalization, which could inspire future manipulation of VLPs for biomedical applications.
资助项目	National Key R&D Program of China[2018YFA0702400] ; National Natural Science Foundation of China[12004438] ; Natural Science Foundation of Shandong Province[ZR2020QB078] ; Fundamental Research Funds for the Central Universities[20CX06011A]
WOS研究方向	Chemistry ; Physics
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000788810500001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/178960]
专题	海洋研究所_海洋腐蚀与防护研究发展中心
通讯作者	Li, Jiawei
作者单位	1.China Univ Petr East China, Sch Mat Sci & Engn, Qingdao 266580, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Environm Corros & Biofouling, Qingdao 266071, Peoples R China 3.China Univ Petr East China, Coll Sci, Qingdao 266580, Peoples R China
推荐引用方式 GB/T 7714	Li, Zhen,Wei, Qi,Qi, Ziqiang,et al. In silico insights into the receptor-mediated endocytosis of virus-like nanoparticles [J]. CHEMICAL PHYSICS LETTERS,2022,790:7.
APA	Li, Zhen,Wei, Qi,Qi, Ziqiang,Zhou, Lixia,&Li, Jiawei.(2022). In silico insights into the receptor-mediated endocytosis of virus-like nanoparticles .CHEMICAL PHYSICS LETTERS,790,7.
MLA	Li, Zhen,et al." In silico insights into the receptor-mediated endocytosis of virus-like nanoparticles ".CHEMICAL PHYSICS LETTERS 790(2022):7.