Massive Heat Shock Protein 70 Genes Expansion and Transcriptional Signatures Uncover Hard Clam Adaptations to Heat and Hypoxia

doi:10.3389/fmars.2022.898669

CORC > 海洋研究所 > 中国科学院海洋研究所 > 海洋生态与环境科学重点实验室

	Massive Heat Shock Protein 70 Genes Expansion and Transcriptional Signatures Uncover Hard Clam Adaptations to Heat and Hypoxia
	Hu, Zhi 1,5,6,7,8,9; Song, Hao 1,5,7,8,9; Feng, Jie 1,5,7,8,9; Zhou, Cong 1,5,6,7,8,9; Yang, Mei-Jie 1,5,7,8,9; Shi, Pu 1,5,6,7,8,9; Yu, Zheng-Lin 4; Li, Yong-Ren 3; Guo, Yong-Jun 3; Li, Hai-Zhou 2
刊名	FRONTIERS IN MARINE SCIENCE
	2022-05-27
卷号	9 页码:14
关键词	Mercenaria mercenaria HSP70 heat hypoxia adaptation
DOI	10.3389/fmars.2022.898669
通讯作者	Zhang, Tao(tzhang@qdio.ac.cn)
英文摘要	Heat shock protein 70 (HSP70) members participate in a wide range of housekeeping and stress-related activities in eukaryotic cells. In marine ecosystems, bivalves encounter abiotic stresses, including high temperatures and low dissolved oxygen. Here, 133 MmHSP70 genes were identified through combined methods including Blastp, HMM and manual filtration, based on the whole Mercenaria mercenaria genome. The MmHSP70 genes were unevenly distributed, and 41 genes (33.08%) were located on Chr 7. Phylogenetic analyses indicated that the MmHSP70 gene family mainly consisted of two clusters and the Hspa12 subfamily underwent lineage-specific expansion. A high-density collinear gene block was observed between M. mercenaria Chr 7 and Cyclina sinensis Chr 14. Tandem duplication MmHSP70 gene pairs experienced different levels of purifying selection, which could be an important source of sequence and functional constraints. MmHSP70 genes showed tissue-specific and stress-specific expression. Most tandem duplication HSP70 gene pairs had high expression under hypoxia stress. HSP70 B2 tandem duplication gene pairs showed significantly increased expression under heat plus severe hypoxia stress. This study provided a comprehensive understanding of the MmHSP70 gene family in the M. mercenaria and laid a significant foundation for further studies on the functional characteristics of MmHSP70 genes during exposure to heat and hypoxia stress.
WOS研究方向	Environmental Sciences & Ecology ; Marine & Freshwater Biology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000810171900001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/179548]
专题	海洋研究所_海洋生态与环境科学重点实验室
通讯作者	Zhang, Tao
作者单位	1.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China 2.Shandong Fu Han Ocean Scitech Co Ltd, Haiyang, Peoples R China 3.Tianjin Agr Univ, Fisheries Coll, Tianjin Key Lab Aqua Ecol & Aquaculture, Tianjin, Peoples R China 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China 5.Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China 7.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao, Peoples R China 8.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao, Peoples R China 9.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Hu, Zhi,Song, Hao,Feng, Jie,et al. Massive Heat Shock Protein 70 Genes Expansion and Transcriptional Signatures Uncover Hard Clam Adaptations to Heat and Hypoxia[J]. FRONTIERS IN MARINE SCIENCE,2022,9:14.
APA	Hu, Zhi.,Song, Hao.,Feng, Jie.,Zhou, Cong.,Yang, Mei-Jie.,...&Zhang, Tao.(2022).Massive Heat Shock Protein 70 Genes Expansion and Transcriptional Signatures Uncover Hard Clam Adaptations to Heat and Hypoxia.FRONTIERS IN MARINE SCIENCE,9,14.
MLA	Hu, Zhi,et al."Massive Heat Shock Protein 70 Genes Expansion and Transcriptional Signatures Uncover Hard Clam Adaptations to Heat and Hypoxia".FRONTIERS IN MARINE SCIENCE 9(2022):14.