Uncommon Polyketides from Penicillium steckii AS-324, a Marine Endozoic Fungus Isolated from Deep-Sea Coral in the Magellan Seamount

doi:10.3390/ijms23116332

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Uncommon Polyketides from Penicillium steckii AS-324, a Marine Endozoic Fungus Isolated from Deep-Sea Coral in the Magellan Seamount
	Hu, Xue-Yi 1,3,4; Li, Xiao-Ming 1,4; Wang, Bin-Gui 1,2,3,4; Meng, Ling-Hong 1,2,4
刊名	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
	2022-06-01
卷号	23 期号:11 页码:13
关键词	marine endozoic fungus Penicillium steckii polyketide derivatives natural products structure elucidation biological activity
DOI	10.3390/ijms23116332
通讯作者	Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Meng, Ling-Hong(menglh@ms.qdio.ac.cn)
英文摘要	Four unusual steckwaic acids E-H (1-4), possessing a rarely described acrylic acid unit at C-4 (1-3) or a double bond between C-12 and C-13 (4) are reported for the first time, along with four new analogues (5-8) and two known congeners (9 and 10). They were purified from the organic extract of Penicillium steckii AS-324, an endozoic fungus obtained from a deep-sea coral Acanthogorgiidae sp., which was collected from the Magellan Seamount at a depth of 1458 m. Their structures were determined by the interpretation of NMR and mass spectroscopic data. The relative and absolute configurations were determined by NOESY correlations, X-ray crystallographic analysis, and ECD calculations. All compounds were tested for their antimicrobial activities against human- and aquatic-pathogenic bacteria and plant-related pathogenic fungi.
资助项目	National Natural Science Foundation of China[U2006203] ; National Natural Science Foundation of China[41976090] ; Natural Science Foundation of Jiangsu province[BK20201211] ; Natural Science Foundation of Jiangsu province[KEXUE2020GZ02]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:000808944800001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/179503]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui; Meng, Ling-Hong
作者单位	1.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Coll Marine Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Hu, Xue-Yi,Li, Xiao-Ming,Wang, Bin-Gui,et al. Uncommon Polyketides from Penicillium steckii AS-324, a Marine Endozoic Fungus Isolated from Deep-Sea Coral in the Magellan Seamount[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(11):13.
APA	Hu, Xue-Yi,Li, Xiao-Ming,Wang, Bin-Gui,&Meng, Ling-Hong.(2022).Uncommon Polyketides from Penicillium steckii AS-324, a Marine Endozoic Fungus Isolated from Deep-Sea Coral in the Magellan Seamount.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(11),13.
MLA	Hu, Xue-Yi,et al."Uncommon Polyketides from Penicillium steckii AS-324, a Marine Endozoic Fungus Isolated from Deep-Sea Coral in the Magellan Seamount".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.11(2022):13.