Tanzawaic Acid Derivatives: Fungal Polyketides from the Deep-Sea Coral-Derived Endozoic Penicillium steckii AS-324

doi:10.1021/acs.jnatprod.2c00211

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	Tanzawaic Acid Derivatives: Fungal Polyketides from the Deep-Sea Coral-Derived Endozoic Penicillium steckii AS-324
	Hu, Xue-Yi 1,2,3; Li, Xiao-Ming 2,3; Wang, Bin-Gui 1,2,3,4; Meng, Ling-Hong 2,3,4
刊名	JOURNAL OF NATURAL PRODUCTS
	2022-05-27
卷号	85 期号:5 页码:1398-1406
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.2c00211
通讯作者	Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Meng, Ling-Hong()
英文摘要	Ten new tanzawaic acids, namely, steckwaic acids A-D (1-4), 11-ketotanzawaic acid D (5), 6,15-dihydroxytanzawaic acid M (6), 15R-methoxytanzawaic acid M (7), 15S-methoxytanzawaic acid M (8), 8-hydroxytanzawaic acid M (9), and 8-hydroxytanzawaic acid B (10), together with four known analogues (11-14), were isolated and identified from the endozoic fungus Penicillium steckii AS-324, which was obtained from a deep-sea Acanthogorgiidae sp. coral that was collected from the Magellan seamount in the Western Pacific Ocean. Structurally, steckwaic acids A-D (1-4) represent the first tanzawaic acid derivatives containing a naphthalene ring. Their structures were elucidated by detailed interpretation of the NMR spectroscopic and mass spectrometric data. X-ray crystallographic analysis and ECD calculations confirmed their structures and absolute configurations. New compounds 1, 5, and 9 exhibited activities against aquatic pathogenic bacteria Micrococcus luteus, Vibrio anguillarum, and Pseudomonas aeruginosa with MICs of 2, 4, and 4 mu g/mL, respectively.
资助项目	National Natural Science Foundation of China[41976090] ; National Natural Science Foundation of China[42176115] ; Natural Science Foundation of Jiangsu Province[BK20201211] ; Natural Science Foundation of Jiangsu Province[KEXUE2020GZ02] ; National Major Science and Technology Infrastructure from the Chinese Academy of Sciences
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000806554600022
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/179461]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui; Meng, Ling-Hong
作者单位	1.Univ Chinese Acad Sci, Coll Marine Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Hu, Xue-Yi,Li, Xiao-Ming,Wang, Bin-Gui,et al. Tanzawaic Acid Derivatives: Fungal Polyketides from the Deep-Sea Coral-Derived Endozoic Penicillium steckii AS-324[J]. JOURNAL OF NATURAL PRODUCTS,2022,85(5):1398-1406.
APA	Hu, Xue-Yi,Li, Xiao-Ming,Wang, Bin-Gui,&Meng, Ling-Hong.(2022).Tanzawaic Acid Derivatives: Fungal Polyketides from the Deep-Sea Coral-Derived Endozoic Penicillium steckii AS-324.JOURNAL OF NATURAL PRODUCTS,85(5),1398-1406.
MLA	Hu, Xue-Yi,et al."Tanzawaic Acid Derivatives: Fungal Polyketides from the Deep-Sea Coral-Derived Endozoic Penicillium steckii AS-324".JOURNAL OF NATURAL PRODUCTS 85.5(2022):1398-1406.