Mediation of mechanically adapted TiCu/TiCuN/CFR-PEEK implants in vascular regeneration to promote bone repair in vitro and in vivo

doi:10.1016/j.jot.2022.02.008

CORC > 金属研究所 > 中国科学院金属研究所

	Mediation of mechanically adapted TiCu/TiCuN/CFR-PEEK implants in vascular regeneration to promote bone repair in vitro and in vivo
	Guo, Yu 1,2; Chen, Chenglong 1,2; Zhang, Shuyuan 1; Ren, Ling 3; Zhao, Yanhui 3; Guo, Wei 2
刊名	JOURNAL OF ORTHOPAEDIC TRANSLATION
	2022-03-01
卷号	33 页码:107-119
关键词	Bone regeneration Carbon fibre -reinforced polyetheretherketone Orthopaedic implant TiCu TiCuN Vascularisation
ISSN号	2214-031X
DOI	10.1016/j.jot.2022.02.008
通讯作者	Ren, Ling(lren@imr.ac.cn) ; Zhao, Yanhui(yhzhao@imr.ac.cn) ; Guo, Wei(bonetumor@163.com)
英文摘要	Background/Objective: TiCu/TiCuN is a multilayer composite coating comprising TiN and Cu, which provides excellent wear resistance and antibacterial properties. However, its applicability as a functional coating has not been widely realised, and several aspects pertaining to its properties must still be explored.Methods: This study uses arc ion-plating technology to apply a TiCu/TiCuN coating on the surface of carbon fibre reinforced (CFR) polyetheretherketone (PEEK) material.The safety and osteogenic activity of TiCu/TiCuN-coated CFR-PEEK materials were explored through cell experiments and animal experiments, and the molecules behind them were verified.Results: The new material exhibits improved mechanical compatibility (mechanical strength and elastic modulus) and superior light transmittance (elimination of metal artifacts and ray refraction during radiology and radiotherapy). The proposed implant delivers excellent biocompatibility for mesenchymal stem cells and human umbilical vein endothelial cells (HUVECs), and it exhibits excellent osteogenic activity both in vitro and in vivo. Additionally, it was determined that the applied TiCu/TiCuN coating aids in upregulating the expression of angiogenesis-related signals (i.e., cluster-of-differentiation 31, alpha-smooth muscle actin, vascular endothelial growth factor receptor, and hypoxia-inducible factor-1 alpha) to promote neovascularisation, which is significant for characterising the mechanism of the coating in promoting bone regeneration. Conclusion: The current results reveal that the TiCu/TiCuN-coated CFR-PEEK implants may emerge as an advanced generation of orthopaedic implants. Translational potential statement: The results of this study indicate that TiCu/TiCuN coating-modified CFR-PEEK materials can promote bone repair through angiogenesis and have broad clinical translation prospects.
资助项目	Capital Health Development Scientific Research Special Project[2151000026] ; Beijing Science and Technology Planning Project[2144000054] ; National Natural Science Foundation of China[82072970]
WOS研究方向	Orthopedics
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000783581400009
资助机构	Capital Health Development Scientific Research Special Project ; Beijing Science and Technology Planning Project ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/172878]
专题	金属研究所_中国科学院金属研究所
通讯作者	Ren, Ling; Zhao, Yanhui; Guo, Wei
作者单位	1.Beijing Key Lab Musculoskeletal Tumor, 11 Xizhimen South St, Beijing 100044, Peoples R China 2.Peking Univ Peoples Hosp, Musculoskeletal Tumor Ctr, 11 Xizhimen South St, Beijing 100044, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shi Changxu Innovat Ctr Adv Mat, 72 Wenhua Rd, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Guo, Yu,Chen, Chenglong,Zhang, Shuyuan,et al. Mediation of mechanically adapted TiCu/TiCuN/CFR-PEEK implants in vascular regeneration to promote bone repair in vitro and in vivo[J]. JOURNAL OF ORTHOPAEDIC TRANSLATION,2022,33:107-119.
APA	Guo, Yu,Chen, Chenglong,Zhang, Shuyuan,Ren, Ling,Zhao, Yanhui,&Guo, Wei.(2022).Mediation of mechanically adapted TiCu/TiCuN/CFR-PEEK implants in vascular regeneration to promote bone repair in vitro and in vivo.JOURNAL OF ORTHOPAEDIC TRANSLATION,33,107-119.
MLA	Guo, Yu,et al."Mediation of mechanically adapted TiCu/TiCuN/CFR-PEEK implants in vascular regeneration to promote bone repair in vitro and in vivo".JOURNAL OF ORTHOPAEDIC TRANSLATION 33(2022):107-119.