Mechanisms of non-coding RNA-modulated alternative splicing in cancer
Wang, Xiaolin1,2,3,4; Hua, Jinghan1,2; Li, Jingxin2; Zhang, Jiahui1,2; Dzakah, Emmanuel Enoch5; Cao, Guozhen1,2; Lin, Wenchu1,3,4
刊名RNA BIOLOGY
2022-12-31
卷号19
关键词Alternative splicing splicing factor cancer progression miRNA lncRNA circRNA
ISSN号1547-6286
DOI10.1080/15476286.2022.2062846
通讯作者Lin, Wenchu(wenchu@hmfl.ac.cn)
英文摘要Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions. Aberrant AS represents a hallmark of cancer, engaged in all stages of tumorigenesis from initiation to metastasis. Accumulating pieces of evidence have revealed the involvement of non-coding RNAs (ncRNAs) in regulating AS in human cancers. In this review, we overview the underlying mechanisms of non-coding RNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) modulated AS at diverse levels in human cancers, and summarize their regulatory functions in tumorigenesis.
资助项目High Magnetic Field Laboratory of Anhui Province
WOS关键词CIRCULAR RNAS ; MESSENGER-RNA ; MYC ; IDENTIFICATION ; TRANSCRIPTION ; COMPLEXITY ; LANDSCAPE ; HALLMARKS ; INSIGHTS ; MALAT1
WOS研究方向Biochemistry & Molecular Biology
语种英语
出版者TAYLOR & FRANCIS INC
WOS记录号WOS:000782921000001
资助机构High Magnetic Field Laboratory of Anhui Province
内容类型期刊论文
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/128665]  
专题中国科学院合肥物质科学研究院
通讯作者Lin, Wenchu
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci Hips, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China
2.Univ Sci & Technol China, Hefei, Anhui, Peoples R China
3.Chinese Acad Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, HIPS, Hefei, Anhui, Peoples R China
4.High Magnet Field Lab Anhui Prov, Hefei, Anhui, Peoples R China
5.Univ Cape Coast, Coll Agr & Nat Sci, Sch Biol Sci, Dept Mol Biol & Biotechnol, Cape Coast, Ghana
推荐引用方式
GB/T 7714
Wang, Xiaolin,Hua, Jinghan,Li, Jingxin,et al. Mechanisms of non-coding RNA-modulated alternative splicing in cancer[J]. RNA BIOLOGY,2022,19.
APA Wang, Xiaolin.,Hua, Jinghan.,Li, Jingxin.,Zhang, Jiahui.,Dzakah, Emmanuel Enoch.,...&Lin, Wenchu.(2022).Mechanisms of non-coding RNA-modulated alternative splicing in cancer.RNA BIOLOGY,19.
MLA Wang, Xiaolin,et al."Mechanisms of non-coding RNA-modulated alternative splicing in cancer".RNA BIOLOGY 19(2022).
个性服务
查看访问统计
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。


©版权所有 ©2017 CSpace - Powered by CSpace