Curcumin Alleviates DSS-Induced Anxiety-Like Behaviors via the Microbial-Brain-Gut Axis

doi:10.1155/2022/6244757

	Curcumin Alleviates DSS-Induced Anxiety-Like Behaviors via the Microbial-Brain-Gut Axis
	Zhang, Fan 1,2,3; Zhou, Yanlin 1,3,4; Chen, Haitao 5,6; Jiang, Hao 1,2,3; Zhou, Feini 1,2,3; Lv, Bin 3,4; Xu, Maosheng 2
刊名	OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
	2022-03-18
卷号	2022
ISSN号	1942-0900
DOI	10.1155/2022/6244757
通讯作者	Lv, Bin(lvbin@medmail.com.cn) ; Xu, Maosheng(xums166@zcmu.edu.cn)
英文摘要	The anxiety and depression caused by inflammatory bowel diseases (IBD) are known to greatly affect the mental health of patients. The mechanism of psychiatric disorders caused by IBD is not fully understood. Previous research has suggested that the gut microbiome plays a key role in IBD. Curcumin is a yellow polyphenol extracted from the rhizome of the ginger plant, which has been shown to have effects against both depression and anxiety. Research has indicated that curcumin affects the gut microbiome and exerts antianxiety and neuroprotective effects through the microbiota-gut-brain axis (MGB). However, whether curcumin can alleviate the psychiatric disorders caused by IBD and how curcumin affects the MGB axis through the gut microbiota have not been fully understood. Therefore, this study was aimed at determining the metabolic parameters and microbiological environment in the peripheral and central nervous system to determine the effects of curcumin against anxiety induced by dextran sulfate sodium salt (DSS) in mice. To elaborate on the link between the gut microbiota and how curcumin alleviates anxiety-like behaviors, we performed a fecal microbiota transplantation (FMT) experiment. The results suggested that curcumin can effectively relieve anxiety-like behaviors caused by DSS in mice. Further, curcumin treatment can alleviate disturbances in the gut microbiota and systemic disorders of lipid metabolism caused by DSS. Finally, through FMT, we verified that curcumin increased phosphatidylcholine in the prefrontal cortex of the mice and alleviated DSS-induced anxiety-like behaviors by modulating specific gut microbiota. We also revealed that Muribaculaceae may be a key part of the gut microbiota for curcumin to alleviate DSS-induced anxiety-like behaviors through the MGB axis.
资助项目	National Natural Science Foundation of China[81971600] ; National Natural Science Foundation of China[81970470] ; National Natural Science Foundation of China[81770535] ; Chinese Medicine Research Program of Zhejiang Province[2019ZA018]
WOS关键词	ALZHEIMERS-DISEASE ; LIPIDS ; COLITIS ; CHOLINE ; PHOSPHATIDYLCHOLINE ; MARKERS ; STRESS
WOS研究方向	Cell Biology
语种	英语
出版者	HINDAWI LTD
WOS记录号	WOS:000783468100002
资助机构	National Natural Science Foundation of China ; Chinese Medicine Research Program of Zhejiang Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/128631]
专题	中国科学院合肥物质科学研究院
通讯作者	Lv, Bin; Xu, Maosheng
作者单位	1.Zhejiang Chinese Med Univ, Sch Clin Med 1, Hangzhou 310053, Zhejiang, Peoples R China 2.Zhejiang Chinese Med Univ, Zhejiang Prov Hosp Tradit Chinese Med, Affiliated Hosp 1, Dept Radiol, Hangzhou 310003, Zhejiang, Peoples R China 3.Zhejiang Chinese Med Univ, Affiliated Hosp 1, Key Lab Digest Pathophysiol Zhejiang Prov, Hangzhou 310006, Zhejiang, Peoples R China 4.Zhejiang Chinese Med Univ, Zhejiang Prov Hosp Tradit Chinese Med, Affiliated Hosp 1, Dept Gastroenterol, Hangzhou 310003, Zhejiang, Peoples R China 5.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 6.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Fan,Zhou, Yanlin,Chen, Haitao,et al. Curcumin Alleviates DSS-Induced Anxiety-Like Behaviors via the Microbial-Brain-Gut Axis[J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2022,2022.
APA	Zhang, Fan.,Zhou, Yanlin.,Chen, Haitao.,Jiang, Hao.,Zhou, Feini.,...&Xu, Maosheng.(2022).Curcumin Alleviates DSS-Induced Anxiety-Like Behaviors via the Microbial-Brain-Gut Axis.OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2022.
MLA	Zhang, Fan,et al."Curcumin Alleviates DSS-Induced Anxiety-Like Behaviors via the Microbial-Brain-Gut Axis".OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2022(2022).