Succinyl rotundic acid inhibits growth and promotes apoptosis in the HeLa cervical cancer cell line

doi:10.1166/mex.2020.1660

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	Succinyl rotundic acid inhibits growth and promotes apoptosis in the HeLa cervical cancer cell line
	Y. F. He,J. M. Sun,M. L. Nang,X. Wang,H. Lin,G. F. Lv,Y. Li,M. H. Duan and H. B. Ye
刊名	Materials Express
	2020
卷号	10 期号:4 页码:571-577
ISSN号	2158-5849
DOI	10.1166/mex.2020.1660
英文摘要	Rotundic acid (RA) is a kind of pentacyclic triterpene saponins, which widely exists in holly and other plants. It has anti-tumor and lipid-lowering effects, and has been widely used in the prevention and treatment of vascular diseases. Succinyl RA (SRA) is a kind of circular acid derivative with strong water solubility. However, SRA's effect and mechanism about the therapy of cervical cancer is still not clarified. The inhibitory effect of SRA on Hela cells and its molecular mechanism were investigated in this study. Hela cell line was used to establish an in vitro model to study the effect of SRA. The effects of SRA on cell proliferation, cell cycle and apoptosis were analyzed by flow cytometry and detected by 3-(4,5-dimethyl thiazole-2-yl)-2, 5-diphenyltetrazole bromide. The experimental results show that SRA can inhibit the growth of Hela and diffusion, inducing cell apoptosis. SRA can also reduce the expression of CyclinD 1 and p21. It was also decreased the expression of apoptosis inhibitor B cell lymphoma (Bcl-2), and increased the expression of Bcl-2-related X-protein and Caspase-3. This study provides evidence for the progress of SRA in inhibiting Hela cells and presents potential applications of SRA as an alternative therapy for cervical cancer.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.ciomp.ac.cn/handle/181722/64927]
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	Y. F. He,J. M. Sun,M. L. Nang,X. Wang,H. Lin,G. F. Lv,Y. Li,M. H. Duan and H. B. Ye. Succinyl rotundic acid inhibits growth and promotes apoptosis in the HeLa cervical cancer cell line[J]. Materials Express,2020,10(4):571-577.
APA	Y. F. He,J. M. Sun,M. L. Nang,X. Wang,H. Lin,G. F. Lv,Y. Li,M. H. Duan and H. B. Ye.(2020).Succinyl rotundic acid inhibits growth and promotes apoptosis in the HeLa cervical cancer cell line.Materials Express,10(4),571-577.
MLA	Y. F. He,J. M. Sun,M. L. Nang,X. Wang,H. Lin,G. F. Lv,Y. Li,M. H. Duan and H. B. Ye."Succinyl rotundic acid inhibits growth and promotes apoptosis in the HeLa cervical cancer cell line".Materials Express 10.4(2020):571-577.