Electrokinetic Translocation of a Deformable Nanoparticle through a Nanopore

doi:10.1021/acsabm.0c00606

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	Electrokinetic Translocation of a Deformable Nanoparticle through a Nanopore
	T. Zhou,J. Ge,L. Shi,Z. Liu,Y. Deng,Y. Peng,X. He,R. Tang and L. Wen
刊名	ACS Applied Bio Materials
	2020
卷号	3 期号:8 页码:5160-5168
ISSN号	25766422
DOI	10.1021/acsabm.0c00606
英文摘要	The nanopore-based biosensing technology is built up on the fluctuation of the ionic current induced by the electrokinetic translation of a particle penetrating the nanopore. It is expected that the current change of a deformable bioparticle is dissimilar from that of a rigid one. This study theoretically investigated the transient translocation process of a deformable particle through a nanopore for the first time. The mathematical model considers the Poisson equation for the electric potential, the Nernst-Planck equations for the ionic transport, the Navier-Stokes equations for the flow field, and the stress-strain equation for the dynamics of the deformable bioparticle. The arbitrary Lagrangian-Eulerian method is used for the fully coupled particle-fluid dynamic interaction. Results show that the deformation degree of the particle, the velocity deviation, and the current is different from the rigid particle. The deformation degree of the particle will reach the maximum when the particle passes a nanopore. Because of the deformation of particles, the total force applied on deformable particles is larger than that of rigid particles, resulting in larger velocity deviation and current deviation. The influences of the ratio of the nanoparticle radius to the Debye length and surface charge density of the nanopore are also studied. The research results illustrate the translocation mechanism of a deformable nanoparticle in the nanopore, which can provide theoretical guidance for the biosensing technology based on the nanopore. 2020 American Chemical Society.
URL标识	查看原文
内容类型	期刊论文
源URL	[http://ir.ciomp.ac.cn/handle/181722/64487]
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	T. Zhou,J. Ge,L. Shi,Z. Liu,Y. Deng,Y. Peng,X. He,R. Tang and L. Wen. Electrokinetic Translocation of a Deformable Nanoparticle through a Nanopore[J]. ACS Applied Bio Materials,2020,3(8):5160-5168.
APA	T. Zhou,J. Ge,L. Shi,Z. Liu,Y. Deng,Y. Peng,X. He,R. Tang and L. Wen.(2020).Electrokinetic Translocation of a Deformable Nanoparticle through a Nanopore.ACS Applied Bio Materials,3(8),5160-5168.
MLA	T. Zhou,J. Ge,L. Shi,Z. Liu,Y. Deng,Y. Peng,X. He,R. Tang and L. Wen."Electrokinetic Translocation of a Deformable Nanoparticle through a Nanopore".ACS Applied Bio Materials 3.8(2020):5160-5168.