Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group
	Liu, Weiping 1; Su, Jia 2,3; Jiang, Jing 1; Li, Xingyao 2,3; Ye, Qingsong 1; Zhou, Hongyu 2; Chen, Jialin 1; Li, Yan2
刊名	SCIENTIFIC REPORTS
	2013-08-19
卷号	3 页码:2464
关键词	CANCER-CELLS AGENTS APOPTOSIS TOXICITY DRUGS
ISSN号	2045-2322
通讯作者	Li, Y (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China. ; liyanb@mail.kib.ac.cn
英文摘要	Two mixed-NH3/amine platinum (II) complexes of 3-dichoroacetoxylcyclobutane-1, 1-dicarboxylate have been prepared in the present study and characterized by elemental analysis and IR, HPLC-MS and(1)H, C-13-NMR. The complexes exist in equilibrium between two position isomeric forms and undergo hydrolysis reaction in aqueous solution, releasing the platinum pharmacophores and dichloroacetate which is a small-molecular cell apoptosis inducer. Both complexes were evaluated for in vitro cytotoxic profile in A549, SGC-7901 and SK-OV-3 caner cells as well as in BEAS-2B normal cells. They exhibit markedly cytoxicity toward cancer cells by selectively inducing the apoptosis of cancer cells, whereas leaving normal cells less affected. They have also the ability to overcome the resistance of SK-OV-3 cancer cells to cisplatin. Our findings offer an alternative novel way to develop platinum drugs which can both overcome the drug resistance and selectively target tumor cells.
学科主题	Multidisciplinary Sciences
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	CANCER-CELLS ; AGENTS ; APOPTOSIS ; TOXICITY ; DRUGS
收录类别	SCI
资助信息	Major State Basic Research Development Program of China [2009CB522300]; National Key R&D Program of China [2012BAE06B08]; 100 Talents Program of the Chinese Academy of Sciences; Natural Science Foundation of China [21161010, 81173076]; Program of Recruited Top Talents of Sciences and Technology of Yunnan Province [2009C1120]
语种	英语
WOS记录号	WOS:000323194900001
公开日期	2013-10-16
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/16701]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Kunming Inst Precious Met, State Key Lab Platinum Grp Met, Kunming 650106, Yunnan, Peoples R China 2.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu, Weiping,Su, Jia,Jiang, Jing,et al. Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group[J]. SCIENTIFIC REPORTS,2013,3:2464.
APA	Liu, Weiping.,Su, Jia.,Jiang, Jing.,Li, Xingyao.,Ye, Qingsong.,...&Li, Yan.(2013).Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group.SCIENTIFIC REPORTS,3,2464.
MLA	Liu, Weiping,et al."Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group".SCIENTIFIC REPORTS 3(2013):2464.