In vivo theranostics with near-infrared-emitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration

doi:10.1038/s41377-018-0090-1

CORC > 长春光学精密机械与物理研究所 > 中国科学院长春光学精密机械与物理研究所

	In vivo theranostics with near-infrared-emitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration
	Bao, Xin; Yuan, Ye; Chen, Jingqin; Zhang, Bohan; Li, Di; Zhou, Ding; Jing, Pengtao; Xu, Guiying; Wang, Yingli; Hola, Kateina
刊名	Bao et al. Light: Science & Applications
	2018
卷号	7 期号:1
关键词	Infrared devices Carbon Medical applications Nanostructured materials Photoacoustic effect Photoluminescence Tumors
ISSN号	20955545
DOI	10.1038/s41377-018-0090-1
英文摘要	Carbon dots that exhibit near-infrared fluorescence (NIR CDs) are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents. Despite progress in the synthesis of NIR CDs, there remains a key obstacle to using them as an in vivo theranostic agent. This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy (PTT) in mouse models (conversion efficiency of 59%) and can be readily visualized by photoluminescence and photoacoustic imaging. The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting. Contrary to all other nanomaterials that have been tested in biomedicine, they are excreted through the bodys renal filtration system. Moreover, after intravenous injection, NIR CDs are accumulated in tumor tissue via passive targeting, without any active species such as antibodies. Due to their accumulation in tumor tissue without the need for intratumor injection, high photothermal conversion, excellent optical and photoacoustic imaging performance, and renal excretion, the developed CDs are suitable for transfer to clinical biomedical practice. 2018, The Author(s).
内容类型	期刊论文
源URL	[http://ir.ciomp.ac.cn/handle/181722/60701]
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	Bao, Xin,Yuan, Ye,Chen, Jingqin,et al. In vivo theranostics with near-infrared-emitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration[J]. Bao et al. Light: Science & Applications,2018,7(1).
APA	Bao, Xin.,Yuan, Ye.,Chen, Jingqin.,Zhang, Bohan.,Li, Di.,...&Qu, Songnan.(2018).In vivo theranostics with near-infrared-emitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration.Bao et al. Light: Science & Applications,7(1).
MLA	Bao, Xin,et al."In vivo theranostics with near-infrared-emitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration".Bao et al. Light: Science & Applications 7.1(2018).