Dynamic Characterization of Single Cells Based on Temporal Cellular Mechanical Properties | |
Ma S(马爽)1,2,3; Zhang, Xiaofang5; Dang D(党丹)4; Wang WX(王文学)2,3; Wang YC(王越超)2,3; Liu LQ(刘连庆)2,3; Wang TL(王天路)5 | |
刊名 | IEEE Transactions on Nanobioscience |
2021 | |
页码 | 1-9 |
关键词 | mechanical properties single cell modelling cell classification systemidentification |
ISSN号 | 1536-1241 |
产权排序 | 1 |
英文摘要 | The mechanical properties of cells play important roles in regulating the physiological activities of cells and reflect the state of macro-organisms. Although many approaches are available for investigating the mechanical properties of cells, the fluidity of cytoplasm across cell boundaries makes characterizing the dynamics of mechanical properties of single cells exceedingly difficult. In this study, we present a single cell characterization method by modelling the dynamics of cellular mechanical properties measured with an atomic force microscope (AFM). The mechanical dynamics of a single cell system was described by a linear model with a mechanical stimulus as virtual input and mechanical property parameters as outputs. The dynamic mechanical properties of a single cell were characterized by the system matrix of the single cell system. The method was used to classify different types of cells, and the experimental results show that the proposed method outperformed conventional methods by achieving an average classification accuracy of over 90%. The developed method can be used to classify different cancer types according to the mechanical properties of tumour cells, which is of great significance for clinically assisted pathological diagnosis. |
语种 | 英语 |
资助机构 | National Key R&D Program of China (Grant No. 2018YFB1304700) ; National Natural Science Foundation of China (Grant Nos. U1908215, 61925307, 91848201, 61903265, 62003338, 61821005, U1813210, 61933008) ; Key Research Program of Frontier Sciences, CAS (Grant No. QYZDB-SSW-JSC008) ; Liaoning Revitalizaiton Talents Program (Grant No. XLYC2002014) ; Natural Science Foundation of Liaoning Province of China (Grant No. 20180550741) ; Joint fund of Science & Technology Department of Liaoning Province ; State Key Laboratory of Robotics, China (Grant No. 2019-KF-01-01) |
内容类型 | 期刊论文 |
源URL | [http://ir.sia.cn/handle/173321/30249] |
专题 | 沈阳自动化研究所_机器人学研究室 |
通讯作者 | Wang WX(王文学); Wang TL(王天路) |
作者单位 | 1.University of Chinese Academy of Sciences, Beijing 100049, China 2.Institutes for robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang 110169, China 3.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China 4.Faculty of Medical Devices, Shenyang Pharmaceutical University, Shenyang 110016, China 5.Department of Radiotherapy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang 110042, China |
推荐引用方式 GB/T 7714 | Ma S,Zhang, Xiaofang,Dang D,et al. Dynamic Characterization of Single Cells Based on Temporal Cellular Mechanical Properties[J]. IEEE Transactions on Nanobioscience,2021:1-9. |
APA | Ma S.,Zhang, Xiaofang.,Dang D.,Wang WX.,Wang YC.,...&Wang TL.(2021).Dynamic Characterization of Single Cells Based on Temporal Cellular Mechanical Properties.IEEE Transactions on Nanobioscience,1-9. |
MLA | Ma S,et al."Dynamic Characterization of Single Cells Based on Temporal Cellular Mechanical Properties".IEEE Transactions on Nanobioscience (2021):1-9. |
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