Study of virus infection procedure using atomic force microscope

CORC > 沈阳自动化研究所 > 中国科学院沈阳自动化研究所 > 机器人学研究室

	Study of virus infection procedure using atomic force microscope
	Yuan S(袁帅)2; Liu, Likai 2; Liu B(刘斌)1; Chu, Tianshu 2; Zhang C(张闯)1; Wang WX(王文学)1
	2019
会议日期	December 6-8, 2019
会议地点	Dali, China
其他题名	Study of virus infection procedure using atomic force microscope.pdf
页码	1526-1531
英文摘要	This work mainly uses AFM to study the procedure of virus infecting cells and the mechanism of action of antiviral drugs. Firstly, the change trend of mechanical properties during cell apoptosis was studied, including normal cells and infected one by virus. The procedure of adhesion change was from soft to hard and then soft, in the same experiment. The Young's modulus was also measured under the same condition. Then the effect of virus dose on the process of infecting cells was studied. By quantitative analysis of the trend of mechanical properties, it was found that the change rate of the mechanical properties would speed up with the number of viruses infecting cells increasing. The quantity increase of the virus will accelerate the process of cell apoptosis. Finally, the anti-viral drug Ribavirin inhibiting the process of virus infecting cells was studied by comparing the two designed experiments. The Ribavirin was found to modify the surface structure of the virus for inhibiting the virus infection.
产权排序	2
会议录	IEEE International Conference on Robotics and Biomimetics, ROBIO 2019
会议录出版者	IEEE
会议录出版地	New York
语种	英语
ISBN号	978-1-7281-6321-5
内容类型	会议论文
源URL	[http://ir.sia.cn/handle/173321/26287]
专题	沈阳自动化研究所_机器人学研究室
通讯作者	Yuan S(袁帅)
作者单位	1.Shenyang Institute of Automation, Chinese Academy of Sciences, State Key Laboratory of Robotics, Shenyang 110016, China 2.Shenyang Jianzhu University, Shenyang, LiaoNing Province, China
推荐引用方式 GB/T 7714	Yuan S,Liu, Likai,Liu B,et al. Study of virus infection procedure using atomic force microscope[C]. 见:. Dali, China. December 6-8, 2019.