Imaging and mapping individual target proteins on clinical lymphoma cells by AFM

CORC > 沈阳自动化研究所 > 中国科学院沈阳自动化研究所 > 机器人学研究室

	Imaging and mapping individual target proteins on clinical lymphoma cells by AFM
	Li M(李密); Liu LQ(刘连庆); Wang YC(王越超); Wang WX(王文学)
	2015
会议日期	November 15-18, 2015
会议地点	Honolulu, HI, USA
页码	84-87
英文摘要	The wide applications of atomic force microscopy (AFM) in the past decade have contributed much to the field of cell biology, providing a lot of novel insights into cellular behaviors at the nanoscale. However, current AFM studies are commonly performed on cell lines cultured in vitro which are quite different from the cells in the human body. Directly investigating the physiological activities on tumor cells from clinical patients is of great significance for helping us to better understand the actual cellular activities taking place in the clinical environment. Under the fluorescence recognition of specific tumor cell surface marker, we have used AFM to investigate the binding affinity and nanoscale distributions of CD20 target protein directly on tumor cells prepared from the bone marrow of lymphoma patients. The results provide a new idea to develop closer links between laboratory study and clinical practice, which may have potential impacts on diverse fields such as drug evaluation and efficacy prediction.
源文献作者	Huawei Technologies Co., Ltd.; IEEE Nanotechnology Council; RSC Advances of the Royal Society of Chemistry; Shenzhen Academy of Robotics; University of Arkansas; University of California at Santa Cruz
产权排序	1
会议录	9th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2015
会议录出版者	IEEE Computer Society
会议录出版地	Washington, DC
语种	英语
ISSN号	2159-6964
ISBN号	978-1-4673-9671-4
内容类型	会议论文
源URL	[http://ir.sia.cn/handle/173321/18756]
专题	沈阳自动化研究所_机器人学研究室
通讯作者	Liu LQ(刘连庆); Wang YC(王越超)
作者单位	1.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, 110016, China 2.Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, 48824, United States
推荐引用方式 GB/T 7714	Li M,Liu LQ,Wang YC,et al. Imaging and mapping individual target proteins on clinical lymphoma cells by AFM[C]. 见:. Honolulu, HI, USA. November 15-18, 2015.