Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights

doi:10.14715/cmb/2021.67.2.28

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	Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights
	Farooqi, Ammad Ahmad 6; Tahir, Fatima ; Fakhar, Maham 5; Butt, Ghazala 5; Pimentel, Tatiana Colombo 4; Wu, Ning 3; Yulaevna, Ishmuratova Margarita 2; Attar, Rukset 1
刊名	CELLULAR AND MOLECULAR BIOLOGY
	2021
卷号	67 期号:2 页码:178-186
关键词	Cancer Apoptosis Signaling Xenografted mice
ISSN号	0145-5680
DOI	10.14715/cmb/2021.67.2.28
通讯作者	Farooqi, Ammad Ahmad(Farooqiammadahmad@gmail.com) ; Butt, Ghazala(dr.ghazalayasmeen@gcu.edu.pk)
英文摘要	The growing complexity of metastasis has sparked tremendous interest in unraveling of the underlying mechanisms which play fundamental role in cancer progression and metastasis. Ground-breaking discoveries in metastasis research have greatly enhanced our understanding about intricate nature of metastasis. Bioactive chemicals obtained from citrus fruits have gained noteworthy appreciation because of significant cancer chemopreventive roles. Deregulated oncogenic signaling cascades play central role in metastasis. Emerging evidence has started to shed light on the metastasis inhibitory properties of naringin, naringenin, tangeretin, nobiletin, hesperidin and hesperetin in different cancer cell lines and xenografted mice. Wnt/13-catenin, TGF/SMAD and NOTCH signaling cascades have been shown to play linchpin role in carcinogenesis and metastasis. There is emerging evidence related to pharmacological targeting of Wnt/13-catenin, TGF/ SMAD and NOTCH by citrus-derived bioactive components. These findings are indeed encouraging and will enable researchers to gain further insights into pharmacological targeting of oncogenic pathways to inhibit and prevent metastasis.
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
语种	英语
出版者	C M B ASSOC
WOS记录号	WOS:000744172400028
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/177929]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Farooqi, Ammad Ahmad; Butt, Ghazala
作者单位	1.Yeditepe Univ, Dept Obstet & Gynecol, Istanbul, Turkey 2.EA Buketov Karaganda Univ, Karaganda, Kazakhstan 3.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 4.Fed Inst Parana IFPR, Campus Paranavai, BR-87703536 Paranaque, Brazil 5.Govt Coll Univ, Dept Bot, Lahore, Pakistan 6.Inst Biomed & Genet Engn IBGE, Dept Mol Oncol, Islamabad, Pakistan
推荐引用方式 GB/T 7714	Farooqi, Ammad Ahmad,Tahir, Fatima,Fakhar, Maham,et al. Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights[J]. CELLULAR AND MOLECULAR BIOLOGY,2021,67(2):178-186.
APA	Farooqi, Ammad Ahmad.,Tahir, Fatima.,Fakhar, Maham.,Butt, Ghazala.,Pimentel, Tatiana Colombo.,...&Attar, Rukset.(2021).Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights.CELLULAR AND MOLECULAR BIOLOGY,67(2),178-186.
MLA	Farooqi, Ammad Ahmad,et al."Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights".CELLULAR AND MOLECULAR BIOLOGY 67.2(2021):178-186.