Hollow structures as drug carriers: Recognition, response, and release

doi:10.1007/s12274-021-3595-5

	Hollow structures as drug carriers: Recognition, response, and release
	Zhao, Decai 1,2; Yang, Nailiang 1,2; Xu, Lekai 2,3,4; Du, Jiang 3,4; Yang, Yang 5,6; Wang, Dan 1,2
刊名	NANO RESEARCH
	2021-07-08
页码	19
关键词	hollow structure drug delivery system carriers spatiotemporal
ISSN号	1998-0124
DOI	10.1007/s12274-021-3595-5
英文摘要	Hollow structures have demonstrated great potential in drug delivery owing to their privileged structure, such as high surface-to-volume ratio, low density, large cavities, and hierarchical pores. In this review, we provide a comprehensive overview of hollow structured materials applied in targeting recognition, smart response, and drug release, and we have addressed the possible chemical factors and reactions in these three processes. The advantages of hollow nanostructures are summarized as follows: hollow cavity contributes to large loading capacity; a tailored structure helps controllable drug release; variable compounds adapt to flexible application; surface modification facilitates smart responsive release. Especially, because the multiple physical barriers and chemical interactions can be induced by multishells, hollow multishelled structure is considered as a promising material with unique loading and releasing properties. Finally, we conclude this review with some perspectives on the future research and development of the hollow structures as drug carriers.
资助项目	National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[21820102002] ; National Natural Science Foundation of China[21971244] ; National Key R&D Program of China[2016YFB0600903]
WOS关键词	MESOPOROUS SILICA NANOPARTICLES ; METAL-ORGANIC FRAMEWORK ; IN-VITRO ; DELIVERY-SYSTEM ; TEMPLATING SYNTHESIS ; SUSTAINED-RELEASE ; ORGANOSILICA NANOCAPSULES ; SHELL NANOPARTICLES ; SEQUENTIAL RELEASE ; LOADING CAPACITY
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	TSINGHUA UNIV PRESS
WOS记录号	WOS:000671718700005
资助机构	National Natural Science Foundation of China ; National Key R&D Program of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/49406]
专题	中国科学院过程工程研究所
通讯作者	Yang, Nailiang; Yang, Yang; Wang, Dan
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Zhengzhou Univ, Sch Mat Sci & Engn, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China 4.Zhengzhou Univ, Sch Mat Sci & Engn, Coll Chem, Zhengzhou 450001, Peoples R China 5.Tongji Univ, Shanghai Pulm Hosp, Sch Med, Dept Thorac Surg, Shanghai 200433, Peoples R China 6.Tongji Univ, Sch Mat Sci & Engn, Shanghai 201804, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Decai,Yang, Nailiang,Xu, Lekai,et al. Hollow structures as drug carriers: Recognition, response, and release[J]. NANO RESEARCH,2021:19.
APA	Zhao, Decai,Yang, Nailiang,Xu, Lekai,Du, Jiang,Yang, Yang,&Wang, Dan.(2021).Hollow structures as drug carriers: Recognition, response, and release.NANO RESEARCH,19.
MLA	Zhao, Decai,et al."Hollow structures as drug carriers: Recognition, response, and release".NANO RESEARCH (2021):19.