Mechanistic insight into morphological transition of Pluronic aggregates in aqueous solution via tuning hydrogen bonding strength

doi:10.1016/j.molliq.2021.115967

	Mechanistic insight into morphological transition of Pluronic aggregates in aqueous solution via tuning hydrogen bonding strength
	Luo, Haiyan 1; Jiang, Kun 3; Wang, Xiaotian 1; Liang, Xiangfeng 2; Liu, Huizhou 1; Li, Yingbo 1
刊名	JOURNAL OF MOLECULAR LIQUIDS
	2021-07-01
卷号	333 页码:9
关键词	Morphology Block copolymer Hydrogen bonding Strength Mechanism
ISSN号	0167-7322
DOI	10.1016/j.molliq.2021.115967
英文摘要	Hydrogen bonding interaction has been increasingly recognized as a viable tool for manipulating the morphology of amphiphilic block copolymers aggregates in selective media. In this regard, mechanistic understanding on the impact of the strength of such an interaction on the morphological transition of the aggregates is of crucial importance for rational design targeting functional assemblies, yet still remains poorly understood. By performing multiple experimental techniques and molecular dynamics simulations (MDS), we here demonstrate how the morphology of Pluronic P123 micelles evolves by introduction of three octane derivatives (i.e., n-octanol, n-octylamine and n-octanoic acid) capable of forming distinct hydrogen bonding strength with P123 in aqueous solution. It is found that the P123-n-octanol mixture exhibits spherical aggregates as P123 alone. However, upon adding n-octylamine, the P123 micelles undergo sphere-short rod-long worm transition in both concentration and temperature-dependent manners. Interestingly, n-octanoic acid brings about a series of morphological transition from sphere, long worm to unilamellar vesicles as the concentration increases and the formed vesicles are fairly stable in the tested temperature range (20-60 degrees C). The nature of the additives acting on the copolymer aggregates was probed by 2D-NMR and MDS. Although both of the hydrophobic and hydrogen bonding interactions between the additives and block copolymers affect the architecture of the copolymer aggregates, the diverse strength of the latter generating from the functional groups (viz. -OH, -NH2 and -COOH) of the additives with the ether oxygen atoms on P123 backbone results in distinct location of the three additives in the micelles, consequently leading to varying micellar morphologies. This work enriches our knowledge of hydrogen bonding driven morphological transition of amphiphilic block copolymers aggregates, and as a result the fabrication of a desired nano-material through fine-tuning the hydrogen bonding strength can be straightforwardly envisaged. (C) 2021 Elsevier B.V. All rights reserved.
资助项目	National Natural Science Foundation of China[21676283] ; National Natural Science Foundation of China[21506221]
WOS关键词	AMPHIPHILIC BLOCK-COPOLYMER ; SALT-INDUCED MICELLIZATION ; TRIBLOCK COPOLYMERS ; PHASE-BEHAVIOR ; SOLUTION-STATE ; MICELLAR ; COMPLEXES ; TEMPERATURE ; VESICLES ; ACID)
WOS研究方向	Chemistry ; Physics
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000648674100071
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/48869]
专题	中国科学院过程工程研究所
通讯作者	Liu, Huizhou; Li, Yingbo
作者单位	1.Chinese Acad Sci, Inst Proc Engn, CAS Key Lab Green Proc & Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao 266061, Peoples R China 3.Qingdao Univ, Sch Chem & Chem Engn, Qingdao 266071, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Luo, Haiyan,Jiang, Kun,Wang, Xiaotian,et al. Mechanistic insight into morphological transition of Pluronic aggregates in aqueous solution via tuning hydrogen bonding strength[J]. JOURNAL OF MOLECULAR LIQUIDS,2021,333:9.
APA	Luo, Haiyan,Jiang, Kun,Wang, Xiaotian,Liang, Xiangfeng,Liu, Huizhou,&Li, Yingbo.(2021).Mechanistic insight into morphological transition of Pluronic aggregates in aqueous solution via tuning hydrogen bonding strength.JOURNAL OF MOLECULAR LIQUIDS,333,9.
MLA	Luo, Haiyan,et al."Mechanistic insight into morphological transition of Pluronic aggregates in aqueous solution via tuning hydrogen bonding strength".JOURNAL OF MOLECULAR LIQUIDS 333(2021):9.