Engineering the Deformability of Albumin-Stabilized Emulsions for Lymph-Node Vaccine Delivery

doi:10.1002/adma.202100106

	Engineering the Deformability of Albumin-Stabilized Emulsions for Lymph-Node Vaccine Delivery
	Song, Tiantian 3,4; Xia, Yufei 1,4,5; Du, Yiqun 4,6; Chen, Michael W.2; Qing, Hong 3; Ma, Guanghui 1,4,5
刊名	ADVANCED MATERIALS
	2021-05-19
页码	10
关键词	albumin‐ stabilized emulsions deformability lymph node targeting vaccines vaccine delivery systems
ISSN号	0935-9648
DOI	10.1002/adma.202100106
英文摘要	A major challenge in vaccine delivery is to achieve robust lymph-node (LN) accumulation, which can capitalize on concentrated immunocytes and cytokines in LNs to stimulate the onset and persistence of adaptive immune responses. Previous attempts at developing vaccine delivery systems have focused on the sizes, charges, or surface ligands but not on their deformability. In fact, the LN homing of antigen-presenting cells depends on deformability to pass through the cellular gaps. Herein, the deformability of albumin-stabilized emulsions is engineered. Owing to self-adaptive deformability, the droplets (approximate to 330 nm) can attach to and deform between cells and adjust their sizes to pass through the endothelial gaps (20-100 nm), favoring direct LN transfer (intercellular pathway). Additionally, owing to relatively large sizes, some emulsions can be retained at the administration sites for potent antigen uptake and activation of APCs as well as LN-targeted delivery of vaccines (intracellular pathway). Compared with solid particles, the dual LN transfer strategy evidently enhances antigen accumulation and activation of LN drainage, potently stimulates cellular immune responses, and increases the survival rate of tumor-bearing mice. Thus, the deformability of albumin-stabilized droplets may offer an efficient strategy for potent LN targeting and enhanced vaccinations.
资助项目	Foundation for Innovative Research Groups of the National Natural Science Foundation of China[21821005] ; Pilot Project of Chinese Academy of Sciences[XDB29040303] ; "From 0 to 1" Original Innovation Project of Basic Frontier Scientific Research Program of Chinese Academy of Sciences[2020000071] ; Youth Project of National Natural Science Foundation of China[21908229] ; Beijing Nova Program of Beijing Municipal Science & Technology Commission[Z201100006820139] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2020000053] ; National Science and Technology Major Project of China[2018ZX10301-103-003] ; Key External Cooperation Program of Chinese Academy of Sciences[122111KYSB20180021] ; Regulations for the Care and Use of Laboratory Animals and Guideline for Ethical Review of Animal (China)[GB/T35892-2018]
WOS关键词	CELL TRAFFICKING ; IN-VIVO ; NANOPARTICLE ; ADJUVANT ; IMPROVE ; SYSTEM
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000652105200001
资助机构	Foundation for Innovative Research Groups of the National Natural Science Foundation of China ; Pilot Project of Chinese Academy of Sciences ; "From 0 to 1" Original Innovation Project of Basic Frontier Scientific Research Program of Chinese Academy of Sciences ; Youth Project of National Natural Science Foundation of China ; Beijing Nova Program of Beijing Municipal Science & Technology Commission ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; National Science and Technology Major Project of China ; Key External Cooperation Program of Chinese Academy of Sciences ; Regulations for the Care and Use of Laboratory Animals and Guideline for Ethical Review of Animal (China)
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/48716]
专题	中国科学院过程工程研究所
通讯作者	Xia, Yufei; Qing, Hong; Ma, Guanghui
作者单位	1.Chinese Acad Sci, Innovat Acad Green Mfg, Beijing 100190, Peoples R China 2.Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China 3.Beijing Inst Technol, Sch Life Sci, Key Lab Mol Med & Biotherapy, Beijing 100081, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Inst Translat Med, Shenzhen 518035, Peoples R China
推荐引用方式 GB/T 7714	Song, Tiantian,Xia, Yufei,Du, Yiqun,et al. Engineering the Deformability of Albumin-Stabilized Emulsions for Lymph-Node Vaccine Delivery[J]. ADVANCED MATERIALS,2021:10.
APA	Song, Tiantian,Xia, Yufei,Du, Yiqun,Chen, Michael W.,Qing, Hong,&Ma, Guanghui.(2021).Engineering the Deformability of Albumin-Stabilized Emulsions for Lymph-Node Vaccine Delivery.ADVANCED MATERIALS,10.
MLA	Song, Tiantian,et al."Engineering the Deformability of Albumin-Stabilized Emulsions for Lymph-Node Vaccine Delivery".ADVANCED MATERIALS (2021):10.