Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a "nanoguard'' for synergistic treatment of synucleinopathies

doi:10.1039/d0mh01542c

	Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a "nanoguard'' for synergistic treatment of synucleinopathies
	Ji, Weihong 1,2; Li, Yan 1; Liu, Ruiyuan 1,2; Lu, Zhiguo 1,2; Liu, Linying 1,2; Shi, Zhuyan 1,2; Shen, Jie 1,2; Zhang, Xin 1
刊名	MATERIALS HORIZONS
	2021-04-01
卷号	8 期号:4 页码:1199-1206
ISSN号	2051-6347
DOI	10.1039/d0mh01542c
英文摘要	Synaptic vesicle-inspired nanoparticles (RT-PPB NPs) as a "nanoguard'' were designed for clearing the toxic a-synuclein aggregates in diseased neurons and preventing the culprits from escaping to affect other normal cells. The NPs could overcome a series of tissue and cellular barriers and controllably release drugs in the diseased neurons, which ensured the optimization of synergistic treatment. This study indicates that the synaptic vesicle-inspired NPs may have the potential to open up a new avenue for the treatment of synucleinopathies, as well as other neurodegenerative diseases.
资助项目	Beijing Natural Science Foundation[L172046] ; Beijing Natural Science Foundation[2192057] ; National High Technology Research and Development Program[2016YFA0200303] ; National Natural Science Foundation of China[21905283] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; Beijing Nova Program[Z201100006820140]
WOS研究方向	Chemistry ; Materials Science
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000639328100022
资助机构	Beijing Natural Science Foundation ; National High Technology Research and Development Program ; National Natural Science Foundation of China ; Beijing Nova Program
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/48544]
专题	中国科学院过程工程研究所
通讯作者	Zhang, Xin
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Ji, Weihong,Li, Yan,Liu, Ruiyuan,et al. Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a "nanoguard'' for synergistic treatment of synucleinopathies[J]. MATERIALS HORIZONS,2021,8(4):1199-1206.
APA	Ji, Weihong.,Li, Yan.,Liu, Ruiyuan.,Lu, Zhiguo.,Liu, Linying.,...&Zhang, Xin.(2021).Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a "nanoguard'' for synergistic treatment of synucleinopathies.MATERIALS HORIZONS,8(4),1199-1206.
MLA	Ji, Weihong,et al."Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a "nanoguard'' for synergistic treatment of synucleinopathies".MATERIALS HORIZONS 8.4(2021):1199-1206.