Biomimetic Nanozymes Based on Coassembly of Amino Acid and Hemin for Catalytic Oxidation and Sensing of Biomolecules

doi:10.1002/smll.202008114

	Biomimetic Nanozymes Based on Coassembly of Amino Acid and Hemin for Catalytic Oxidation and Sensing of Biomolecules
	Geng, Rui 1; Chang, Rui 2; Zou, Qianli 2,3; Shen, Guizhi 2,4; Jiao, Tifeng 1; Yan, Xuehai 2
刊名	SMALL
	2021-03-24
页码	6
关键词	amino acid hemin nanozymes peroxidase self‐ assembly
ISSN号	1613-6810
DOI	10.1002/smll.202008114
英文摘要	Nanoassemblies based on self-assembly of biological building blocks are promising in mimicking the nanostructures, properties, and functionalities of natural enzymes. However, it remains a challenge to design of biomimetic nanozymes with tunable nanostructures and enhanced catalytic activities starting from simple biomolecules. Herein, the construction of nanoassemblies through coassembly of an amphiphilic amino acid and hemin is reported. The nanostructures and morphologies of the resulting nanoassemblies are readily controlled by tuning the molar ratio between the amino acid and hemin, thus leading to tailored peroxidase-mimicking activities of the nanoassemblies. Importantly, the optimized nanoassemblies exhibit a remarkable catalytic efficiency that is comparable to the natural counterpart when considering molecular mass along with good robustness in multiple catalytic cycles. The nanoassemblies are effectively integrated as biomimetic nanozymes in a sensing system for catalytic detection of glucose. Therefore, this work demonstrates that nanozymes with advanced catalytic capabilities can be constructed by self-assembly of minimalist biological building blocks and may thus promote the rational design and catalytic applications of biomimetic nanozymes.
资助项目	National Natural Science Foundation of China[22025207] ; National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21977095] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; Key Research Program of Nanjing IPE Institute of Green Manufacturing Industry[E0010722]
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000631980200001
资助机构	National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; Key Research Program of Nanjing IPE Institute of Green Manufacturing Industry
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/47975]
专题	中国科学院过程工程研究所
通讯作者	Zou, Qianli; Jiao, Tifeng; Yan, Xuehai
作者单位	1.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Hebei, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China 4.Nanjing IPE Inst Green Mfg Ind, Nanjing 211135, Peoples R China
推荐引用方式 GB/T 7714	Geng, Rui,Chang, Rui,Zou, Qianli,et al. Biomimetic Nanozymes Based on Coassembly of Amino Acid and Hemin for Catalytic Oxidation and Sensing of Biomolecules[J]. SMALL,2021:6.
APA	Geng, Rui,Chang, Rui,Zou, Qianli,Shen, Guizhi,Jiao, Tifeng,&Yan, Xuehai.(2021).Biomimetic Nanozymes Based on Coassembly of Amino Acid and Hemin for Catalytic Oxidation and Sensing of Biomolecules.SMALL,6.
MLA	Geng, Rui,et al."Biomimetic Nanozymes Based on Coassembly of Amino Acid and Hemin for Catalytic Oxidation and Sensing of Biomolecules".SMALL (2021):6.