Excellent Trace Detection of Proteins on TiO2 Nanotube Substrates through Novel Topography Optimization

doi:10.1021/acs.jpcc.0c08793

	Excellent Trace Detection of Proteins on TiO2 Nanotube Substrates through Novel Topography Optimization
	Dong, Yihui 1,5; Wu, Na 5; Ji, Xiaoyan 3; Laaksonen, Aatto 2,3,4,5; Lu, Xiaohua 5; Zhang, Suojiang 1
刊名	JOURNAL OF PHYSICAL CHEMISTRY C
	2020-12-17
卷号	124 期号:50 页码:27790-27800
ISSN号	1932-7447
DOI	10.1021/acs.jpcc.0c08793
英文摘要	For improving the surface-enhanced Raman scattering (SERS) performance of nanomaterials to achieve trace detection of proteins and complex biological systems, structural and topographical control is one of the important strategies. In this work, a facial and effective method to optimize the topography of TiO2 nanotube arrays (TNAs) is demonstrated, together with a significant enhancement of the SERS performance of cytochrome C (Cyt C) on TNAs. An enhancement factor (EF) up to 10(4), which is obtained with the newly developed method on the basis of the quantification of atomic force microscopy (AFM)-measured interaction force, is achieved, corresponding to a superior detection limit of Cyt C down to 10(-7) M. The main reason is that adjusting the fluoride contents in an electrolyte (from 0.4 to 0.1 wt %) can reduce the content and sizes of cracks, as well as the tube ruptures of TNAs, where the fluoride content at 0.2 wt % can successfully provide the excellent and optimized topography of TNAs. The TNAs with the optimized topography, especially those with larger tube diameters, demonstrated the importance of structural integrity on a remarkably excellent SERS performance in the trace detection of proteins. The proposed method will stimulate the development and optimization of the active substrate on the SERS applications in biology, bioanalysis, and nanoscience.
资助项目	National Natural Science Foundation of China[21838004] ; Swedish Science Council ; Ministry of Research and Innovation of Romania (CNCS.UEFISCDI within PNCDI III)[PN-III-P4-ID-PCCF-2016-0050]
WOS关键词	ENHANCED RAMAN-SCATTERING ; SERS ; ARRAYS ; NANOPARTICLES ; SPECTROSCOPY ; AMPLIFICATION ; NANOMATERIALS ; SENSITIVITY ; DEPENDENCE ; MOLECULES
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000608876900054
资助机构	National Natural Science Foundation of China ; Swedish Science Council ; Ministry of Research and Innovation of Romania (CNCS.UEFISCDI within PNCDI III)
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/43291]
专题	中国科学院过程工程研究所
通讯作者	Lu, Xiaohua; Zhang, Suojiang
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Beijing Key Lab Ion Liquids Clean Proc, CAS Key Lab Green Proc & Engn,State Key Lab Multi, Beijing 100190, Peoples R China 2.Stockholm Univ, Dept Mat & Environm Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden 3.Lulea Univ Technol, Energy Engn, Div Energy Sci, S-97187 Lulea, Sweden 4.Petru Poni Inst Macromol Chem, Ctr Adv Res Bionanoconjugates & Biopolymers, Iasi 700487, Romania 5.Nanjing Tech Univ, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Peoples R China
推荐引用方式 GB/T 7714	Dong, Yihui,Wu, Na,Ji, Xiaoyan,et al. Excellent Trace Detection of Proteins on TiO2 Nanotube Substrates through Novel Topography Optimization[J]. JOURNAL OF PHYSICAL CHEMISTRY C,2020,124(50):27790-27800.
APA	Dong, Yihui,Wu, Na,Ji, Xiaoyan,Laaksonen, Aatto,Lu, Xiaohua,&Zhang, Suojiang.(2020).Excellent Trace Detection of Proteins on TiO2 Nanotube Substrates through Novel Topography Optimization.JOURNAL OF PHYSICAL CHEMISTRY C,124(50),27790-27800.
MLA	Dong, Yihui,et al."Excellent Trace Detection of Proteins on TiO2 Nanotube Substrates through Novel Topography Optimization".JOURNAL OF PHYSICAL CHEMISTRY C 124.50(2020):27790-27800.