Self-Activatable Photo-Extracellular Vesicle for Synergistic Trimodal Anticancer Therapy

doi:10.1002/adma.202005562

	Self-Activatable Photo-Extracellular Vesicle for Synergistic Trimodal Anticancer Therapy
	Ding, Jingjing 1; Lu, Guihong 2; Nie, Weidong 1; Huang, Li-Li 1; Zhang, Yahui 1; Fan, Wenlin 1; Wu, Guanghao 1; Liu, Houli 1; Xie, Hai-Yan 1
刊名	ADVANCED MATERIALS
	2021-01-12
页码	12
关键词	chemotherapy extracellular vesicle immunotherapy photodynamic therapy tumor microenvironment
ISSN号	0935-9648
DOI	10.1002/adma.202005562
英文摘要	Extracellular vesicles (EVs) hold great potential in both disease treatment and drug delivery. However, accurate drug release from EVs, as well as the spontaneous treatment effect cooperation of EVs and drugs at target tissues, is still challenging. Here, an engineered self-activatable photo-EV for synergistic trimodal anticancer therapy is reported. M1 macrophage-derived EVs (M1 EVs) are simultaneously loaded with bis[2,4,5-trichloro-6-(pentyloxycarbonyl) phenyl] oxalate (CPPO), chlorin e6 (Ce6), and prodrug aldoxorubicin (Dox-EMCH). After administration, the as-prepared system actively targets tumor cells because of the tumor-homing capability of M1 EVs, wherein M1 EVs repolarize M2 to M1 macrophages, which not only display immunotherapy effects but also produce H2O2. The reaction between H2O2 and CPPO generates chemical energy that activates Ce6, creating both chemiluminescence for imaging and singlet oxygen (O-1(2)) for photodynamic therapy (PDT). Meanwhile, O-1(2)-induced membrane rupture leads to the release of Dox-EMCH, which is then activated and penetrates the deep hypoxic areas of tumors. The synergism of immunotherapy, PDT, and chemotherapy results in potent anticancer efficacy, showing great promise to fight cancers.
资助项目	National Science Foundation of China[21874011] ; National Science Foundation of China[91859213] ; National Science Foundation of China[22025401]
WOS关键词	TUMOR-ASSOCIATED MACROPHAGES ; HYDROGEN-PEROXIDE ; EXOSOMES ; DRUG ; NANOPARTICLES ; DELIVERY ; CHEMILUMINESCENCE ; PACLITAXEL ; PHENOTYPE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000606809100001
资助机构	National Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/43154]
专题	中国科学院过程工程研究所
通讯作者	Xie, Hai-Yan
作者单位	1.Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Ding, Jingjing,Lu, Guihong,Nie, Weidong,et al. Self-Activatable Photo-Extracellular Vesicle for Synergistic Trimodal Anticancer Therapy[J]. ADVANCED MATERIALS,2021:12.
APA	Ding, Jingjing.,Lu, Guihong.,Nie, Weidong.,Huang, Li-Li.,Zhang, Yahui.,...&Xie, Hai-Yan.(2021).Self-Activatable Photo-Extracellular Vesicle for Synergistic Trimodal Anticancer Therapy.ADVANCED MATERIALS,12.
MLA	Ding, Jingjing,et al."Self-Activatable Photo-Extracellular Vesicle for Synergistic Trimodal Anticancer Therapy".ADVANCED MATERIALS (2021):12.