Sprayed Pickering emulsion with high antibacterial activity for wound healing

doi:10.1016/j.pnsc.2020.08.001

	Sprayed Pickering emulsion with high antibacterial activity for wound healing
	Bao, Xieru 1,2; Wu, Jie 1,2,3,4; Ma, Guanghui 1,2,3,4
刊名	PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL
	2020-10-01
卷号	30 期号:5 页码:669-676
关键词	Pickering emulsion Wound healing Chitosan nanoparticles High viscosity Antibacterial activity
ISSN号	1002-0071
DOI	10.1016/j.pnsc.2020.08.001
英文摘要	Effective treatment of wound injuries can prevent infections and promote healing. In this work, a sprayed Pickering emulsion composed of chitosan nanoparticles, tea tree oil and curcumin was formulated. The shear thinning behaviour allowed this Pickering emulsion to spray even with a high viscosity provided by the aqueous phase containing chitosan nanoparticles. Moreover, the Pickering emulsion could recover to the high viscosity after spraying onto the wounds, leading to the long residence time and intimate contact. In addition, the Pickering emulsion provided a carrier to encapsulate the tea tree oil, which caused sustained-release effects and further strengthened tea tree oil's antibacterial activity towards the Gram-negative Escherichia coli (E. coli), Gram-positive Staphylococcus aureus (S. aureus) and Gram-positive methicillin-resistant Staphylococcus aureus (MRSA). Besides, this multi-phase system offered a platform to load with hydrophobic curcumin, leading to better synergistic healing effects. Meanwhile, the Pickering emulsion avoided the irritation and toxicity related to surfactants, which was far safer than the classical emulsion especially when used in the defective skin. All these excellent properties endowed this sprayed Pickering emulsion with promising prospects for wound healing.
资助项目	National Key R&D Program of China, China[2018YFC0311303] ; Key Research Program of the Chinese Academy of Sciences, China[KFZD-SW-218] ; International Cooperation Project of the Chinese Academy of Sciences, China[122111KYSB20180021] ; National Natural Science Foundation of China[21776287]
WOS关键词	TEA TREE OIL ; IN-VITRO ; HYDROGEL ; SKIN ; PARTICLES ; NANOPARTICLES ; MEMBRANE ; DELIVERY ; SYSTEM
WOS研究方向	Materials Science ; Science & Technology - Other Topics
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000604439100004
资助机构	National Key R&D Program of China, China ; Key Research Program of the Chinese Academy of Sciences, China ; International Cooperation Project of the Chinese Academy of Sciences, China ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/43039]
专题	中国科学院过程工程研究所
通讯作者	Wu, Jie; Ma, Guanghui
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Beijing, Peoples R China 4.Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing, Peoples R China
推荐引用方式 GB/T 7714	Bao, Xieru,Wu, Jie,Ma, Guanghui. Sprayed Pickering emulsion with high antibacterial activity for wound healing[J]. PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL,2020,30(5):669-676.
APA	Bao, Xieru,Wu, Jie,&Ma, Guanghui.(2020).Sprayed Pickering emulsion with high antibacterial activity for wound healing.PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL,30(5),669-676.
MLA	Bao, Xieru,et al."Sprayed Pickering emulsion with high antibacterial activity for wound healing".PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL 30.5(2020):669-676.