Chitosan Oligosaccharides Coupling Inhibits Bacterial Biofilm-Related Antibiotic Resistance against Florfenicol

doi:10.3390/molecules25246043

	Chitosan Oligosaccharides Coupling Inhibits Bacterial Biofilm-Related Antibiotic Resistance against Florfenicol
	Yuan, Xianghua 1; Liu, Jing 2; Li, Ruilian 2,3; Zhou, Junlin 1; Wei, Jinhua 2; Jiao, Siming 2; Wang, Zhuo A.2,3; Du, Yuguang 2,3
刊名	MOLECULES
	2020-12-01
卷号	25 期号:24 页码:10
关键词	biofilm florfenicol chitosan oligosaccharide antibiotic resistance
DOI	10.3390/molecules25246043
英文摘要	The formation of bacterial biofilms has increased the resistance of bacteria to various environmental factors and is tightly associated with many persistent and chronic bacterial infections. Herein we design a strategy conjugating florfenicol, an antibiotic commonly used in the treatment of streptococcus, with the antimicrobial biomaterial, chitosan oligosaccharides. The results demonstrated that the florfenicol-COS conjugate (F-COS) efficiently eradicated the mature Streptococcus hyovaginalis biofilm, apparently inhibiting drug resistance to florfenicol. A quantity of 250 mu g/mL F-COS showed effective inhibitory activity against planktonic cells and biofilm of the bacteria, and a 4-fold improvement of the F-COS compared to unmodified florfenicol was observed. Furthermore, the conjugate showed a broad-spectrum activity against both Gram-positive and Gram-negative bacteria. It suggested that F-COS might have a potential for application in the treatment of biofilm-related infections.
资助项目	National Key R&D Program of China[2017YFD0502300] ; National Natural Science Foundation of China[31670809]
WOS关键词	STREPTOCOCCUS-SUIS ; CHLORAMPHENICOL ; PHARMACOKINETICS ; MENINGITIS ; AMINE
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	MDPI
WOS记录号	WOS:000603239700001
资助机构	National Key R&D Program of China ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/42975]
专题	中国科学院过程工程研究所
通讯作者	Wang, Zhuo A.; Du, Yuguang
作者单位	1.Sichuan Normal Univ, Coll Life Sci, Chengdu 610101, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Coll Chem & Chem Engn, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Xianghua,Liu, Jing,Li, Ruilian,et al. Chitosan Oligosaccharides Coupling Inhibits Bacterial Biofilm-Related Antibiotic Resistance against Florfenicol[J]. MOLECULES,2020,25(24):10.
APA	Yuan, Xianghua.,Liu, Jing.,Li, Ruilian.,Zhou, Junlin.,Wei, Jinhua.,...&Du, Yuguang.(2020).Chitosan Oligosaccharides Coupling Inhibits Bacterial Biofilm-Related Antibiotic Resistance against Florfenicol.MOLECULES,25(24),10.
MLA	Yuan, Xianghua,et al."Chitosan Oligosaccharides Coupling Inhibits Bacterial Biofilm-Related Antibiotic Resistance against Florfenicol".MOLECULES 25.24(2020):10.