Hydrogel-based preparation of cell aggregates for biomedical applications

doi:10.1016/j.apmt.2020.100747

	Hydrogel-based preparation of cell aggregates for biomedical applications
	Zhang, Jiabin 1; Yun, Seonho 1; Du, Yuguang 4; Zannettino, Andrew 2; Zhang, Hu 1,3
刊名	APPLIED MATERIALS TODAY
	2020-09-01
卷号	20 页码:19
关键词	2D 3D Hydrogel Cell aggregate Biomedical application
ISSN号	2352-9407
DOI	10.1016/j.apmt.2020.100747
英文摘要	Cell aggregates are widely used either as in-vitro models for drug screening, fundamental studies on disease progression and developmental biology, as well as in-vivo injectable cells for tissue regeneration. Compared to single-cell suspensions, cell aggregates retain superior cell viability, mimic in-vivo microenvironments and enhance functional properties, such as superior anti-inflammatory properties of mesenchymal stem/stromal cell aggregates or enhanced albumin production by hepatocyte aggregates. Cell aggregates can be either prepared by conventional spontaneous aggregation, or advanced substrate based and technology-assisted methods, which have been well described in previous reviews. However, hydrogel-based preparation of cell aggregates is a novel, hitherto rarely considered method compared to conventional preparation of cell aggregates, such as hanging drops and commercial AggreWellTM plates. This review will mainly focus on two-dimensional (2D) hydrogel surface-based and three-dimensional (3D) hydrogel embedding-based preparation of cell aggregates by revealing the underlying mechanisms and highlighting some of their potential biomedical applications. (c) 2020 Elsevier Ltd. All rights reserved.
资助项目	ARC Discovery Project[DP160104632] ; Medical Advancement Without Animal (MAWA) Trust ; IPE-UoA Scholarship (BES)
WOS关键词	MESENCHYMAL STEM-CELLS ; POLY(ETHYLENE GLYCOL) HYDROGELS ; IN-VITRO ; HYALURONIC-ACID ; EMBRYOID BODIES ; STROMAL CELLS ; THERAPEUTIC NEOVASCULARIZATION ; CHONDROGENIC DIFFERENTIATION ; TISSUE RECONSTRUCTION ; RESPONSIVE HYDROGELS
WOS研究方向	Materials Science
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000598356100014
资助机构	ARC Discovery Project ; Medical Advancement Without Animal (MAWA) Trust ; IPE-UoA Scholarship (BES)
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/42916]
专题	中国科学院过程工程研究所
通讯作者	Zannettino, Andrew; Zhang, Hu
作者单位	1.Univ Adelaide, Sch Chem Engn, Adelaide, SA 5005, Australia 2.Univ Adelaide, Adelaide Med Sch, Adelaide, SA 5001, Australia 3.Keck Grad Inst, Henry E Riggs Sch Appl Life Sci, Claremont, CA 91711 USA 4.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jiabin,Yun, Seonho,Du, Yuguang,et al. Hydrogel-based preparation of cell aggregates for biomedical applications[J]. APPLIED MATERIALS TODAY,2020,20:19.
APA	Zhang, Jiabin,Yun, Seonho,Du, Yuguang,Zannettino, Andrew,&Zhang, Hu.(2020).Hydrogel-based preparation of cell aggregates for biomedical applications.APPLIED MATERIALS TODAY,20,19.
MLA	Zhang, Jiabin,et al."Hydrogel-based preparation of cell aggregates for biomedical applications".APPLIED MATERIALS TODAY 20(2020):19.