Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors

doi:10.1002/anie.202010005

	Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors
	Li, Yongxin 4; Sun, Pan 2; Zhao, Luyang 1; Yan, Xuehai 1; Ng, Dennis K. P.3; Lo, Pui-Chi 4
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2020-10-15
页码	12
关键词	catalase hypoxia photodynamic therapy phthalocyanine self-assembly
ISSN号	1433-7851
DOI	10.1002/anie.202010005
英文摘要	A facile approach to assemble catalase-like photosensitizing nanozymes with a self-oxygen-supplying ability was developed. The process involved Fe3+-driven self-assembly of fluorenylmethyloxycarbonyl (Fmoc)-protected amino acids. By adding a zinc(II) phthalocyanine-based photosensitizer (ZnPc) and the hypoxia-inducible factor 1 (HIF-1) inhibitor acriflavine (ACF) during the Fe3+-promoted self-assembly of Fmoc-protected cysteine (Fmoc-Cys), the nanovesicles Fmoc-Cys/Fe@Pc and Fmoc-Cys/Fe@Pc/ACF were prepared, which could be disassembled intracellularly. The released Fe(3+)could catalyze the transformation of H(2)O(2)enriched in cancer cells to oxygen efficiently, thereby ameliorating the hypoxic condition and promoting the photosensitizing activity of the released ZnPc. With an additional therapeutic component, Fmoc-Cys/Fe@Pc/ACF exhibited higher in vitro and in vivo photodynamic activities than Fmoc-Cys/Fe@Pc, demonstrating the synergistic effect of ZnPc and ACF.
资助项目	Research Grants Council of the Hong Kong Special Administrative Region[11300719]
WOS关键词	PHOTODYNAMIC THERAPY ; HIGHLY EFFICIENT ; NANOPARTICLES ; STRATEGY ; ACID
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000577647500001
资助机构	Research Grants Council of the Hong Kong Special Administrative Region
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/42383]
专题	中国科学院过程工程研究所
通讯作者	Yan, Xuehai; Ng, Dennis K. P.; Lo, Pui-Chi
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, CAS Key Lab Green Proc & Engn, Beijing 100190, Peoples R China 3.Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China 4.City Univ Hong Kong, Dept Biomed Sci, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Li, Yongxin,Sun, Pan,Zhao, Luyang,et al. Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020:12.
APA	Li, Yongxin,Sun, Pan,Zhao, Luyang,Yan, Xuehai,Ng, Dennis K. P.,&Lo, Pui-Chi.(2020).Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,12.
MLA	Li, Yongxin,et al."Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020):12.