Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy

doi:10.1002/adma.202002085

	Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy
	Qing, Shuang 2,3; Lyu, Chengliang 2; Zhu, Li 1,3; Pan, Chao 1; Wang, Shuang 2; Li, Feng 2; Wang, Jianghua 2,3; Yue, Hua 2; Gao, Xiaoyong 2; Jia, Rongrong 4
刊名	ADVANCED MATERIALS
	2020-10-05
页码	14
关键词	bacterial outer membrane vesicles biomineralization cancer immunotherapy tumor microenvironment reprogramming
ISSN号	0935-9648
DOI	10.1002/adma.202002085
英文摘要	The highly immunosuppressive tumor microenvironment (TME) in solid tumors often dampens the efficacy of immunotherapy. In this study, bacterial outer membrane vesicles (OMVs) are demonstrated as powerful immunostimulants for TME reprogramming. To overcome the obstacles of antibody-dependent clearance and high toxicity induced by OMVs upon intravenous injection (a classic clinically relevant delivery mode), calcium phosphate (CaP) shells are employed to cover the surface of OMVs, which enables potent OMV-based TME reprograming without side effects. Meanwhile, the pH-sensitive CaP shells facilitate the neutralization of acidic TME, leading to highly beneficial M2-to-M1 polarization of macrophages for improved antitumor effect. Moreover, the outer shells can be integrated with functional components like folic acid or photosensitizer agents, which facilitates the use of the OMV-based platform in combination therapies for a synergic therapeutic effect.
资助项目	National Natural Science Foundation of China[21821005] ; National Key R&D Program of China[2017YFA0207900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303] ; Regulations for the Care and Use of Laboratory Animals and Guideline for Ethical Review of Animal (China)[GB/T35892-2018]
WOS关键词	T-CELLS ; IMMUNE CELLS ; TGF-BETA ; CANCER ; IMMUNOGENICITY ; IMMUNOTHERAPY ; ANTIBODY ; IMPROVE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000574885100001
资助机构	National Natural Science Foundation of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Regulations for the Care and Use of Laboratory Animals and Guideline for Ethical Review of Animal (China)
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/42264]
专题	中国科学院过程工程研究所
通讯作者	Wei, Wei; Ma, Guanghui
作者单位	1.Beijing Inst Biotechnol, State Key Lab Pathogen & Biosecur, 20 Dongda St, Beijing 100071, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 Bei Er Tiao, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Gastroenterol, 1111 Xianxia Rd, Shanghai 200336, Peoples R China
推荐引用方式 GB/T 7714	Qing, Shuang,Lyu, Chengliang,Zhu, Li,et al. Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy[J]. ADVANCED MATERIALS,2020:14.
APA	Qing, Shuang.,Lyu, Chengliang.,Zhu, Li.,Pan, Chao.,Wang, Shuang.,...&Ma, Guanghui.(2020).Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy.ADVANCED MATERIALS,14.
MLA	Qing, Shuang,et al."Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy".ADVANCED MATERIALS (2020):14.