Hollow Mesoporous Silica Nanoparticles Loaded with Eugenol for Regulating the Central Nervous System

doi:10.1166/jbn.2020.2919

	Hollow Mesoporous Silica Nanoparticles Loaded with Eugenol for Regulating the Central Nervous System
	Wang, Jianze 2,3; Lu, Zhiguo 3,4; Shen, Jie 3,4; Peng, Huan 3,4; Zhang, Tianlu 3,4; Niu, Yunwei 1,5; Xiao, Zuobing 1,5; Hao, Jifu 2; Zhang, Xin 3
刊名	JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
	2020-05-01
卷号	16 期号:5 页码:652-658
关键词	Hollow Mesoporous Silica Nanoparticles Eugenol Slow Release Stress Relief Anti-Anxiety
ISSN号	1550-7033
DOI	10.1166/jbn.2020.2919
英文摘要	Fragrances are extensively applied in food, daily chemicals, tobacco and medicine industries. However, too strong volatility of fragrances results in a fast release rate, thereby reducing the usage time of aromatherapy products. Although loading fragrances into nanomaterials is capable of slowing their rates of release, the encapsulation efficiency of traditional nanomaterials is very low, and the nanomaterials themselves are not stable. Herein, hollow mesoporous silica nanoparticles (hMSNs) were designed for encapsulation of eugenol and he nano-fragrance was named EG@hMSNs. The structure of IP: 127.0.0.1 On: Sat, 19 Sep 2020 06:40:19 hMSNs was stable and the encapsulatin rate of eugnol reached 46.5%. Beids, EG@hMSNs could significantly slow Copyright: American Scientific P blishers the release rate of eugenol. Subsequently, the EG@hMSNs were testified that they had positive roles in stress relief by Delivered by Ingenta open field tests. The molecular mechanisms of these positive effects on the central nervous system were then explored. Furthermore, the preparation method of hMSCs was simple, and the preparation cost was low. Therefore, EG@hMSNs are expected to be industrially produced and have a great application prospect.
资助项目	National High Technology Research and Development Program[2016YFA0200303] ; Beijing Natural Science Foundation[L172046,2192057] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[51573188]
WOS关键词	DRUG-DELIVERY ; BREAST-CANCER ; FRAGRANCE ; MICELLES ; CURCUMIN ; RELEASE ; ANXIETY ; CHEMISTRY ; LIPOSOMES ; CARRIERS
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER SCIENTIFIC PUBLISHERS
WOS记录号	WOS:000573055400001
资助机构	National High Technology Research and Development Program ; Beijing Natural Science Foundation ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/42239]
专题	中国科学院过程工程研究所
通讯作者	Hao, Jifu; Zhang, Xin
作者单位	1.Shanghai Res Inst Fragrance & Flavor Ind, Shanghai 200232, Peoples R China 2.Shandong First Med Univ & Shandong Acad Med Sci, Sch Pharmaceut Sci, Tai An 271016, Shandong, Peoples R China 3.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 5.Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 200233, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jianze,Lu, Zhiguo,Shen, Jie,et al. Hollow Mesoporous Silica Nanoparticles Loaded with Eugenol for Regulating the Central Nervous System[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2020,16(5):652-658.
APA	Wang, Jianze.,Lu, Zhiguo.,Shen, Jie.,Peng, Huan.,Zhang, Tianlu.,...&Zhang, Xin.(2020).Hollow Mesoporous Silica Nanoparticles Loaded with Eugenol for Regulating the Central Nervous System.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,16(5),652-658.
MLA	Wang, Jianze,et al."Hollow Mesoporous Silica Nanoparticles Loaded with Eugenol for Regulating the Central Nervous System".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 16.5(2020):652-658.