Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy

doi:10.1016/j.jconrel.2020.06.015

	Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy
	Zhang, Fan 2,3; Lu, Guihong 1; Wen, Xiaolei 3; Li, Feng 1; Ji, Xiaoyuan 2; Li, Qianqian 2; Wu, Meiying 2; Cheng, Qinzhen 2; Yu, Yongkang 2; Tang, Jing 2
刊名	JOURNAL OF CONTROLLED RELEASE
	2020-10-10
卷号	326 页码:131-139
关键词	Magnetic nanoparticles Photothermal therapy Immunotherapy Synergism Cancer
ISSN号	0168-3659
DOI	10.1016/j.jconrel.2020.06.015
英文摘要	As the combination of photothermal therapy (PTT) with immunotherapy provides an effective strategy in cancer treatment, a magnetic nanoparticle delivery system was constructed to load indocyanine green (ICG) and immunostimulator R837 hydrochloride (R837) for spatio-temporally PTT/immunotherapy synergism in cancer. This delivery system is composed of Fe3O4 magnetic nanoparticles (MPs) as the core to load ICG and polyethylene glycol polyphenols (DPA-PEG) as the coating layer to load R837, which formed R837 loaded polyphenols coating ICG loaded magnetic nanoparticles (MIRDs). After intravenous injection, the formed MIRDs resulted in long circulation, magnetic resonance imaging (MRI) guides, and magnetic targeting. Once targeting to the tumor, the MIRDs with the near-infrared (NIR) irradiation caused tumor ablation and resulted in tumor-associated antigens releasing to induce the body's immunological response, which was markedly improved it to attack the tumors with the R837 releasing from the outer DPA-PEG. In this case, the synergism of the PTT and immunotherapy inhibited tumor growth, metastasis and recurrence, which resulted in potent anticancer therapeutic effects with few side effect.
资助项目	National Natural Science Foundation of China[31922042] ; National Natural Science Foundation of China[31800842] ; National Natural Science Foundation of China[81771966] ; National Natural Science Foundation of China[81801843] ; National Natural Science Foundation of China[81971737] ; Fundamental Research Funds for the Central Universities[31610008] ; Fundamental Research Funds for the Central Universities[2019PT320028] ; Program for the Top-notch Young Talents of Hebei Province[BJ2016025]
WOS关键词	PHOTODYNAMIC THERAPY ; CHECKPOINT BLOCKADE ; PHOTOTHERMAL THERAPY ; IMMUNITY
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000572083700003
资助机构	National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Program for the Top-notch Young Talents of Hebei Province
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/42193]
专题	中国科学院过程工程研究所
通讯作者	Mei, Lin
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Shenzhen 518107, Peoples R China 3.Hebei Normal Univ Sci & Technol, Hebei Key Lab Act Components & Funct Nat Prod, Qinhuangdao 066004, Hebei, Peoples R China 4.Chinese Acad Med Sci & Peking Union Med Coll, Inst Biomed Engn, Tianjin Key Lab Biomed Mat, Key Lab Biomat & Nanotechnol Canc Immunotherapy, Tianjin 300192, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Fan,Lu, Guihong,Wen, Xiaolei,et al. Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy[J]. JOURNAL OF CONTROLLED RELEASE,2020,326:131-139.
APA	Zhang, Fan.,Lu, Guihong.,Wen, Xiaolei.,Li, Feng.,Ji, Xiaoyuan.,...&Mei, Lin.(2020).Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy.JOURNAL OF CONTROLLED RELEASE,326,131-139.
MLA	Zhang, Fan,et al."Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/immunotherapy".JOURNAL OF CONTROLLED RELEASE 326(2020):131-139.