SLC7A7 is a prognostic biomarker correlated with immune infiltrates in non-small cell lung cancer

doi:10.1186/s12935-021-01781-7

	SLC7A7 is a prognostic biomarker correlated with immune infiltrates in non-small cell lung cancer
	Dai,Wumin 2; Feng,Jianguo 2; Hu,Xiao 3; Chen,Yongyi 1; Gu,Qing 3; Gong,Wangang 2; Feng,Tingting 4; Wu,Jie 1
刊名	Cancer Cell International
	2021-02-15
卷号	21 期号:1
关键词	SLC7A7 Lymphocytes Tumor-infiltrating Prognosis Non-small cell lung cancer
DOI	10.1186/s12935-021-01781-7
英文摘要	AbstractBackgroundSLC7A7 (solute carrier family 7, amino acid transporter light chain, y?+?L system, member 7) is a critical gene in the regulation of cationic amino acid transport. However, the relationships between SLC7A7 and prognosis and tumor-infiltrating lymphocytes in different cancers remain unclear.MethodsSLC7A7 expression was analyzed using the Oncomine database and Tumor Immune Estimation Resource (TIMER) site. The enrichment of the GO (Gene Oncology)?and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways was conducted by DAVID.?We evaluated the influence of SLC7A7 on clinical prognosis using the PrognoScan database. The functional state of SLC7A7 in various types of cancers was analyzed by CancerSEA. The relationships between SLC7A7 and cancer immune infiltrates was investigated by TIMER. Furthermore, correlations between SLC7A7 expression and gene marker sets of immune infiltrates were analyzed by TIMER and Gene Expression Profiling Interactive Analysis (GEPIA). The expression of SLC7A7 was verified by GEO database and immunohistochemistry.ResultsA lung cancer cohort study (GSE31210) showed that high SLC7A7 expression was associated with poor overall survival (OS) and relapse-free survival (RFS). In addition, SLC7A7 had a significant impact on the prognosis of diverse cancers. SLC7A7 expression was positively correlated with infiltrating levels of CD4?+?and CD8?+?T cells, macrophages, neutrophils and dendritic cells (DCs) in non-small cell lung cancer (NSCLC). SLC7A7 expression was also strongly correlated with various immune marker sets in NSCLC.ConclusionsThese results indicated a role for SLC7A7 in infiltration of CD8?+?T cells, CD4?+?T cells, tumor-associated macrophages (TAMs), neutrophils and DCs in multiple cancers, and regulation of T cell exhaustion and Tregs in NSCLC. These findings suggest that SLC7A7 could be served as a biomarker for prognosis and immune infiltration in NSCLC.
语种	英语
出版者	BioMed Central
WOS记录号	BMC:10.1186/S12935-021-01781-7
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/41978]
专题	中国科学院过程工程研究所
通讯作者	Dai,Wumin
作者单位	1.Cancer Hospital of University of Chinese Academy of Sciences; Clinical Laboratory 2.Cancer Hospital of University of Chinese Academy of Sciences; Research center 3.Cancer Hospital of University of Chinese Academy of Sciences; Department of Abdominal Oncology 4.Cancer Hospital of University of Chinese Academy of Sciences; Department of Thoracic Oncology Radiotherapy
推荐引用方式 GB/T 7714	Dai,Wumin,Feng,Jianguo,Hu,Xiao,et al. SLC7A7 is a prognostic biomarker correlated with immune infiltrates in non-small cell lung cancer[J]. Cancer Cell International,2021,21(1).
APA	Dai,Wumin.,Feng,Jianguo.,Hu,Xiao.,Chen,Yongyi.,Gu,Qing.,...&Wu,Jie.(2021).SLC7A7 is a prognostic biomarker correlated with immune infiltrates in non-small cell lung cancer.Cancer Cell International,21(1).
MLA	Dai,Wumin,et al."SLC7A7 is a prognostic biomarker correlated with immune infiltrates in non-small cell lung cancer".Cancer Cell International 21.1(2021).