Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy

doi:10.1002/advs.202001108

	Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy
	Wang, Jianghua 1,2; Wang, Shuang 1; Ye, Tong 1,2; Li, Feng 1,2; Gao, Xiaoyong 1; Wang, Yan 1,2; Ye, Peng 1; Qing, Shuang 1,2; Wang, Changlong 1,2; Yue, Hua 1
刊名	ADVANCED SCIENCE
	2020-08-15
页码	17
关键词	delivery modes hydrogels lymph nodes nanovaccines tumor immunotherapy
DOI	10.1002/advs.202001108
英文摘要	Nanovaccines have attracted booming interests in vaccinology studies, but the profound impacts of their delivery mode on immune response remain unrealized. Herein, immunostimulatory CpG-modified tumor-derived nanovesicles (CNVs) are used as a nanovaccine testbed to initially evaluate the impacts of three distinct delivery modes, including mono-pulse CNVs, staggered-pulse CNVs, and gel-confined CNVs. Fundamentally, delivery mode has enormous impacts on the immunomodulatory effects, altering the spatiotemporal distribution of nanovaccine residence and dendritic cell-T cell interaction in lymph nodes, and finally affecting subsequent T cell-mediated immune performance. As a result, the gel-confined delivery mode offers the best therapeutic performance in multiple tumor models. When extending evaluation to examine how the various delivery modes impact the performance of liposome-based nanovaccines, similar trends in intralymph node distribution and antitumor effect are observed. This work provides a strong empirical foundation that nanovaccine researchers should position delivery mode near the top of their considerations for the experimental design, which should speed up nanovaccine development and facilitate efficient selection of appropriate delivery modes in the clinic.
资助项目	Innovative Research Group Project of the National Natural Science Foundation of China[21821005] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303] ; National Key Research and Development Program of China[2017YFA0207900] ; Beijing Municipal Natural Science Foundation[2202056]
WOS关键词	CELLS IN-VIVO ; DENDRITIC CELLS ; LYMPH-NODE ; QUATERNIZED CHITOSAN ; VACCINE DELIVERY ; HYDROGEL ; NANOPARTICLES ; ENCAPSULATION ; BIOMATERIALS ; ANTIGENS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	WILEY
WOS记录号	WOS:000565309100001
资助机构	Innovative Research Group Project of the National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Key Research and Development Program of China ; Beijing Municipal Natural Science Foundation
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/41902]
专题	中国科学院过程工程研究所
通讯作者	Wei, Wei; Ma, Guanghui
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Jianghua,Wang, Shuang,Ye, Tong,et al. Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy[J]. ADVANCED SCIENCE,2020:17.
APA	Wang, Jianghua.,Wang, Shuang.,Ye, Tong.,Li, Feng.,Gao, Xiaoyong.,...&Ma, Guanghui.(2020).Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy.ADVANCED SCIENCE,17.
MLA	Wang, Jianghua,et al."Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy".ADVANCED SCIENCE (2020):17.