Acid-Activatable Transmorphic Peptide-Based Nanomaterials for Photodynamic Therapy | |
Sun, Bingbing1; Chang, Rui2; Cao, Shoupeng1; Yuan, Chengqian2; Zhao, Luyang2; Yang, Haowen4; Li, Junbai3; Yan, Xuehai2; van Hest, Jan C. M.1 | |
刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION |
2020-09-02 | |
页码 | 8 |
关键词 | Fibrillar Transformation Peptides Photodynamic Therapy Photosensitizers Self-assembly |
ISSN号 | 1433-7851 |
DOI | 10.1002/anie.202008708 |
英文摘要 | Inspired by the dynamic morphology control of molecular assemblies in biological systems, we have developed pH-responsive transformable peptide-based nanoparticles for photodynamic therapy (PDT) with prolonged tumor retention times. The self-assembled peptide-porphyrin nanoparticles transformed into nanofibers when exposed to the acidic tumor microenvironment, which was mainly driven by enhanced intermolecular hydrogen bond formation between the protonated molecules. The nanoparticle transformation into fibrils improved their singlet oxygen generation ability and enabled high accumulation and long-term retention at tumor sites. Strong fluorescent signals of these nanomaterials were detected in tumor tissue up to 7 days after administration. Moreover, the peptide assemblies exhibited excellent anti-tumor efficacy via PDT in vivo. This in situ fibrillar transformation strategy could be utilized to design effective stimuli-responsive biomaterials for long-term imaging and therapy. |
资助项目 | Dutch Ministry of Education, Culture and Science[024.001.035] ; Eurotech Postdoc Programme, under the Marie Skodowska-Curie grant[754462] ; National Natural Science Fund BRICS STI Framework Programme of China[51861145304] ; Innovation Research Community Science Fund of National Natural Science Foundation of China[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] |
WOS关键词 | Pi-pi-stacking ; Electrostatic Repulsion ; Nanoparticles ; Cancer ; Photosensitizers ; Combination ; Retention ; Ph |
WOS研究方向 | Chemistry |
语种 | 英语 |
出版者 | WILEY-V C H VERLAG GMBH |
WOS记录号 | WOS:000566420900001 |
资助机构 | Dutch Ministry of Education, Culture and Science ; Eurotech Postdoc Programme, under the Marie Skodowska-Curie grant ; National Natural Science Fund BRICS STI Framework Programme of China ; Innovation Research Community Science Fund of National Natural Science Foundation of China ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/41866] |
专题 | 中国科学院过程工程研究所 |
通讯作者 | Yan, Xuehai; van Hest, Jan C. M. |
作者单位 | 1.Eindhoven Univ Technol, Bioorgan Chem, Inst Complex Mol Syst, Dept Biomed Engn, POB 513, NL-5600 MB Eindhoven, Netherlands 2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Colloid Interface & Chem Thermodynam, Inst Chem, Beijing 100190, Peoples R China 4.Eindhoven Univ Technol, Lab Immunoengn, Dept Biomed Engn, Inst Complex Mol Syst, NL-5600 MB Eindhoven, Netherlands |
推荐引用方式 GB/T 7714 | Sun, Bingbing,Chang, Rui,Cao, Shoupeng,et al. Acid-Activatable Transmorphic Peptide-Based Nanomaterials for Photodynamic Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020:8. |
APA | Sun, Bingbing.,Chang, Rui.,Cao, Shoupeng.,Yuan, Chengqian.,Zhao, Luyang.,...&van Hest, Jan C. M..(2020).Acid-Activatable Transmorphic Peptide-Based Nanomaterials for Photodynamic Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,8. |
MLA | Sun, Bingbing,et al."Acid-Activatable Transmorphic Peptide-Based Nanomaterials for Photodynamic Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020):8. |
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