Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis

doi:10.1016/j.colsurfa.2020.124804

	Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis
	Wei, Peng 1; Ye, Zhou 1; Cao, Shuya 1; Bai, Shuo 4; Seeberger, Peter H.3; Yin, Jian 1; Hu, Jing 2
刊名	COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
	2020-08-05
卷号	598 页码:7
关键词	Nanomicelle Leishmaniasis Mannose receptor
ISSN号	0927-7757
DOI	10.1016/j.colsurfa.2020.124804
英文摘要	Drugs used to treat visceral leishmaniasis (VL) have severe side effects and face increasing resistance. We have created a mannose-functionalized nanomicelle carrying two drugs amphotericin B (AmB) and doxorubicin (DOX). The nanomicelles AmB&DOX@MCC preferentially target macrophages where Leishmania parasites reside and replicate, by the interaction between mannose residues on the micelle and mannose receptors (MRs) on the macrophage membrane. The combination of AmB and DOX leads to enhanced anti-leishmanial therapeutic efficacy through a synergistic effect. The mannose-fabricated nanomicelle is a promising formulation for leishmaniasis treatment.
资助项目	National Natural Science Foundation of China[31700706] ; National Natural Science Foundation of China[21877052] ; Natural Science Foundation of Jiangsu Province[BK20180030] ; Fundamental Research Funds for the Central Universities[JUSRP51712B] ; Max Planck Society International Partner Group Program ; National Key R&D Program of China[2018YFA0901700] ; National First-class Discipline Program of Light Industry Technology and Engineering[LITE2018-14] ; China Scholarship Council ; Max-Planck Society
WOS关键词	IN-VITRO ; TARGETED DELIVERY ; HYBRID HYDROGELS ; INTERVENTION ; SYSTEM
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000561642700006
资助机构	National Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province ; Fundamental Research Funds for the Central Universities ; Max Planck Society International Partner Group Program ; National Key R&D Program of China ; National First-class Discipline Program of Light Industry Technology and Engineering ; China Scholarship Council ; Max-Planck Society
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/41770]
专题	中国科学院过程工程研究所
通讯作者	Yin, Jian; Hu, Jing
作者单位	1.Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Carbohydrate Chem & Biotechnol, Lihu Ave 1800, Wuxi, Jiangsu, Peoples R China 2.Jiangnan Univ, Wuxi Sch Med, Lihu Ave 1800, Wuxi 214122, Jiangsu, Peoples R China 3.Max Planck Inst Colloids & Interfaces, Dept Biomol Syst, D-14476 Potsdam, Germany 4.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wei, Peng,Ye, Zhou,Cao, Shuya,et al. Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2020,598:7.
APA	Wei, Peng.,Ye, Zhou.,Cao, Shuya.,Bai, Shuo.,Seeberger, Peter H..,...&Hu, Jing.(2020).Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,598,7.
MLA	Wei, Peng,et al."Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 598(2020):7.