Minimal metallo-nanozymes constructed through amino acid coordinated self-assembly for hydrolase-like catalysis

doi:10.1016/j.cej.2020.124987

	Minimal metallo-nanozymes constructed through amino acid coordinated self-assembly for hydrolase-like catalysis
	Han, Jingjing 1,2; Zou, Qianli 1; Su, Weiwei 1; Yan, Xuehai 1,2,3
刊名	CHEMICAL ENGINEERING JOURNAL
	2020-08-15
卷号	394 页码:6
关键词	Amino acids Metal ion Self-assembly Metallo-nanozyme Catalytic hydrolyzation
ISSN号	1385-8947
DOI	10.1016/j.cej.2020.124987
英文摘要	Bioinspired nanozymes are promising in mimicking natural processes and developing function-enhanced architectures. However, constructing artificial enzyme systems with catalytic efficiencies rivaling that of natural enzymes in a minimal principle is challenging. Herein, we report the construction of minimal metallo-nanozymes through amino acid coordinated self-assembly by using amino acid derivatives and zinc (II) ions as the building blocks, reminiscent of the components of the catalytic architectures in natural hydrolases. The obtained metallonanozymes possess high and robust activity comparable to that of natural lipase in catalytically hydrolyzing phenyl acetate. In addition, catalytic performance of the metallo-nanozymes can be facilely optimized by changing the ratio between the building blocks and the introduction of additional biomolecules. The metallonanozymes also show catalytic activity in producing acetylsalicylic acid through the hydrolyzation of a prodrug, benorilate. This work highlights the minimal principle and excellent catalytic performance of stable metallonanozymes, opening up immense opportunities in the development of highly efficient nanozymes and catalytic prodrug conversion.
资助项目	National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21977095] ; National Natural Science Foundation of China[21821005] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; Youth Innovation Promotion Association CAS[2019051]
WOS关键词	ENZYME ; COMPLEXES ; HYDROLYSIS ; SITES
WOS研究方向	Engineering
语种	英语
出版者	ELSEVIER SCIENCE SA
WOS记录号	WOS:000551901000047
资助机构	National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; Youth Innovation Promotion Association CAS
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/41488]
专题	中国科学院过程工程研究所
通讯作者	Yan, Xuehai
作者单位	1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Ctr Mesosci, Inst Proc Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Han, Jingjing,Zou, Qianli,Su, Weiwei,et al. Minimal metallo-nanozymes constructed through amino acid coordinated self-assembly for hydrolase-like catalysis[J]. CHEMICAL ENGINEERING JOURNAL,2020,394:6.
APA	Han, Jingjing,Zou, Qianli,Su, Weiwei,&Yan, Xuehai.(2020).Minimal metallo-nanozymes constructed through amino acid coordinated self-assembly for hydrolase-like catalysis.CHEMICAL ENGINEERING JOURNAL,394,6.
MLA	Han, Jingjing,et al."Minimal metallo-nanozymes constructed through amino acid coordinated self-assembly for hydrolase-like catalysis".CHEMICAL ENGINEERING JOURNAL 394(2020):6.