Coassembly-Induced Transformation of Dipeptide Amyloid-Like Structures into Stimuli-Responsive Supramolecular Materials

doi:10.1021/acsnano.0c02138

	Coassembly-Induced Transformation of Dipeptide Amyloid-Like Structures into Stimuli-Responsive Supramolecular Materials
	Ji, Wei 4; Yuan, Chengqian 3; Chakraborty, Priyadarshi 4; Makam, Pandeeswar 4; Bera, Santu 4; Rencus-Lazar, Sigal 4; Li, Junbai 2; Yan, Xuehai 3; Gazit, Ehud 1,4
刊名	ACS NANO
	2020-06-23
卷号	14 期号:6 页码:7181-7190
关键词	amyloid-like structure self-assembly dipeptide stimuli-responsive supramolecular chemistry
ISSN号	1936-0851
DOI	10.1021/acsnano.0c02138
英文摘要	Conformational transition of proteins and peptides into highly stable, beta-sheet-rich structures is observed in many amyloid-associated neurodegenerative disorders, yet the precise mechanism of amyloid formation at the molecular level remains poorly understood due to the complex molecular structures. Short peptides provide simplified models for studying the molecular basis of the assembly mechanism that governs beta-sheet fibrillation processes underlying the formation and inhibition of amyloid-like structures. Herein, we report a supramolecular coassembly strategy for the inhibition and transformation of stable beta-sheet-rich amyloid-derived dipeptide self-assemblies into adaptable secondary structural fibrillar assemblies by mixing with bipyridine derivatives. The interplay between the type and mixing ratio of bipyridine derivatives allowed the variable coassembly process with stimuli-responsive functional properties, studied by various experimental characterizations and computational methods. Furthermore, the resulting coassemblies showed functional redox- and photoresponsive properties, making them promising candidates for controllable drug release and fluorescent imprint. This work presents a coassembly strategy not only to explore the mechanism of amyloid-like structure formation and inhibition at the molecular level but also to manipulate amyloid-like structures into responsive supramolecular coassemblies for material science and biotechnology applications.
资助项目	European Research Council under the European Union Horizon 2020 research and innovation program[694426] ; National Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21802144] ; National Natural Science Foundation of China[21802143] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS关键词	BETA-SHEET ; PEPTIDE ASSEMBLIES ; ALPHA-HELIX ; DIPHENYLALANINE ; HYDROGELS ; FIBRILS ; NANOCARRIERS ; ORGANIZATION ; AGGREGATION ; TRANSITION
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000543744100077
资助机构	European Research Council under the European Union Horizon 2020 research and innovation program ; National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/41313]
专题	中国科学院过程工程研究所
通讯作者	Li, Junbai; Yan, Xuehai; Gazit, Ehud
作者单位	1.Tel Aviv Univ, Dept Mat Sci & Engn, Iby & Aladar Fleischman Fac Engn, IL-6997801 Tel Aviv, Israel 2.Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 4.Tel Aviv Univ, Dept Mol Microbiol & Biotechnol, George S Wise Fac Life Sci, IL-6997801 Tel Aviv, Israel
推荐引用方式 GB/T 7714	Ji, Wei,Yuan, Chengqian,Chakraborty, Priyadarshi,et al. Coassembly-Induced Transformation of Dipeptide Amyloid-Like Structures into Stimuli-Responsive Supramolecular Materials[J]. ACS NANO,2020,14(6):7181-7190.
APA	Ji, Wei.,Yuan, Chengqian.,Chakraborty, Priyadarshi.,Makam, Pandeeswar.,Bera, Santu.,...&Gazit, Ehud.(2020).Coassembly-Induced Transformation of Dipeptide Amyloid-Like Structures into Stimuli-Responsive Supramolecular Materials.ACS NANO,14(6),7181-7190.
MLA	Ji, Wei,et al."Coassembly-Induced Transformation of Dipeptide Amyloid-Like Structures into Stimuli-Responsive Supramolecular Materials".ACS NANO 14.6(2020):7181-7190.