Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination

doi:10.1126/sciadv.aay7735

	Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination
	Xi, Xiaobo 2; Ye, Tong 1,2; Wang, Shuang 1; Na, Xiangming 1; Wang, Jianghua 1,2; Qing, Shuang 1,2; Gao, Xiaoyong 1; Wang, Changlong 1,2; Li, Feng 1,2; Wei, Wei 1,2
刊名	SCIENCE ADVANCES
	2020-05-01
卷号	6 期号:21 页码:16
ISSN号	2375-2548
DOI	10.1126/sciadv.aay7735
英文摘要	Therapeutic cancer vaccines that harness the immune system to reject cancer cells have shown great promise for cancer treatment. Although a wave of efforts have spurred to improve the therapeutic effect, unfavorable immunization microenvironment along with a complicated preparation process and frequent vaccinations substantially compromise the performance. Here, we report a novel microcapsule-based formulation for high-performance cancer vaccinations. The special self-healing feature provides a mild and efficient paradigm for antigen microencapsulation. After vaccination, these microcapsules create a favorable immunization microenvironment in situ, wherein antigen release kinetics, recruited cell behavior, and acid surrounding work in a synergetic manner. In this case, we can effectively increase the antigen utilization, improve the antigen presentation, and activate antigen presenting cells. As a result, effective T cell response, potent tumor inhibition, antimetastatic effects, and prevention of postsurgical recurrence are achieved with various types of antigens, while neoantigen was encapsuled and evaluated in different tumor models.
资助项目	National Key R&D Program of China[2017YFA0207900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303] ; National Natural Science Foundation of China[21622608] ; National Natural Science Foundation of China[21821005]
WOS关键词	SYNTHETIC VACCINES ; IMMUNE-RESPONSES ; DENDRITIC CELLS ; DELIVERY ; IMMUNOTHERAPY ; ANTIGENS ; MICROENCAPSULATION ; NANOPARTICLES ; ENCAPSULATION ; ADJUVANTS
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	AMER ASSOC ADVANCEMENT SCIENCE
WOS记录号	WOS:000537235300007
资助机构	National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/40980]
专题	中国科学院过程工程研究所
通讯作者	Wei, Wei; Ma, Guanghui
作者单位	1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Xi, Xiaobo,Ye, Tong,Wang, Shuang,et al. Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination[J]. SCIENCE ADVANCES,2020,6(21):16.
APA	Xi, Xiaobo.,Ye, Tong.,Wang, Shuang.,Na, Xiangming.,Wang, Jianghua.,...&Ma, Guanghui.(2020).Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination.SCIENCE ADVANCES,6(21),16.
MLA	Xi, Xiaobo,et al."Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination".SCIENCE ADVANCES 6.21(2020):16.