Boron-based nanosheets for combined cancer photothermal and photodynamic therapy | |
Kang, Yong2,3; Ji, Xiaoyuan1; Li, Zhengjun2; Su, Zhiguo2; Zhang, Songping2 | |
刊名 | JOURNAL OF MATERIALS CHEMISTRY B |
2020-06-07 | |
卷号 | 8期号:21页码:4609-4619 |
ISSN号 | 2050-750X |
DOI | 10.1039/d0tb00070a |
英文摘要 | Tumor phototherapy is of great significance for the expansion and advancement of cancer treatment methods. Herein, two-dimensional boron nanosheets (B NSs) with a thickness of 2.4 nm exhibiting an excellent photothermal conversion performance were developed via a simple liquid phase ultrasonic stripping method. Following the loading of the photosensitizer agent chlorin e6 (Ce6) and subsequent modification with poly(allylamine hydrochloride) (PAH) and poly(acrylic acid) (PAA), a B@Ce6-PAH-PAA NS nanomedicine exhibiting dual modal imaging-guided cancer photothermal therapy (PTT) and photodynamic therapy (PDT) properties, as well as outstanding stability was developed. The suitable nano-size (120 nm) of B@Ce6-PAH-PAA NSs can allow drugs to target tumor tissue with an enhanced permeability and retention effect (EPR). The cytotoxicity experiments demonstrated that B@Ce6-PAH-PAA NSs exhibited good biocompatibility even at high concentrations. Furthermore, the in vitro and in vivo experiments showed the excellent synergistic therapeutic effect of this nanomedicine for PTT and PDT. |
资助项目 | National Natural Science Foundation of China[21676276] ; National Natural Science Foundation of China[81801826] ; Science, Technology & Innovation Commission of Shenzhen Municipality[JCYJ20180307153300735] |
WOS关键词 | Ws2 Nanosheets ; Phosphorus ; Exfoliation ; Borophene ; Growth |
WOS研究方向 | Materials Science |
语种 | 英语 |
出版者 | ROYAL SOC CHEMISTRY |
WOS记录号 | WOS:000538170900005 |
资助机构 | National Natural Science Foundation of China ; Science, Technology & Innovation Commission of Shenzhen Municipality |
内容类型 | 期刊论文 |
源URL | [http://ir.ipe.ac.cn/handle/122111/40897] |
专题 | 中国科学院过程工程研究所 |
通讯作者 | Ji, Xiaoyuan; Zhang, Songping |
作者单位 | 1.Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Guangzhou 510275, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Kang, Yong,Ji, Xiaoyuan,Li, Zhengjun,et al. Boron-based nanosheets for combined cancer photothermal and photodynamic therapy[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(21):4609-4619. |
APA | Kang, Yong,Ji, Xiaoyuan,Li, Zhengjun,Su, Zhiguo,&Zhang, Songping.(2020).Boron-based nanosheets for combined cancer photothermal and photodynamic therapy.JOURNAL OF MATERIALS CHEMISTRY B,8(21),4609-4619. |
MLA | Kang, Yong,et al."Boron-based nanosheets for combined cancer photothermal and photodynamic therapy".JOURNAL OF MATERIALS CHEMISTRY B 8.21(2020):4609-4619. |
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