Dipeptide Self-assembled Hydrogels with Shear-Thinning and Instantaneous Self-healing Properties Determined by Peptide Sequences

doi:10.1021/acsami.0c03038

	Dipeptide Self-assembled Hydrogels with Shear-Thinning and Instantaneous Self-healing Properties Determined by Peptide Sequences
	Ren, Peng 2,3; Li, Jingtao 1; Zhao, Luyang 2; Wang, Anhe 2; Wang, Meiyue 2; Li, Jieling 2; Jian, Honglei 2; Li, Xiaoou 1; Yan, Xuehai 2; Bai, Shuo 2,3
刊名	ACS APPLIED MATERIALS & INTERFACES
	2020-05-13
卷号	12 期号:19 页码:21433-21440
关键词	dipeptide self-assembly shear-thinning hydrogel self-healing endoscopic submucosal dissection
ISSN号	1944-8244
DOI	10.1021/acsami.0c03038
英文摘要	Dipeptide self-assembled hydrogels have potential biomedical applications because of their great biocompatibility, bioactivity, and tunable physicochemical properties, which can be modulated in the molecular level by design of amino acid sequences. Herein, a series of dipeptides (Fmoc-FL, -YL, -LL, and -YA) are designed to form shear-thinning hydrogels with self-healing and tunable mechanical properties by adjusting the synergetic effect of hydrophobic interactions (p-p stacking and hydrophobic effect) and hydrogen bonds of peptides through substitution of amino acid residues. The enhancement of hydrophobic interactions is a primary factor to promote mechanical rigidity of hydrogels, and strong hydrogen-bonding interactions between molecules contribute to the instantaneous self-healing property, which is supported by experimental studies (FTIR, CD, SEM, AFM, and rheology) and molecular dynamics simulations. The injectable dipeptide hydrogels were certified as an ideal endoscopic submucosal dissection filler to make operation convenient and secure in mice and living mini-pig's experiments with a longer duration time, higher stiffness, and lower inflammatory response than commercial clinical fillers.
资助项目	National Natural Science Foundation of China[21774132] ; National Natural Science Foundation of China[21703253] ; China-Japan Friendship Hospital Research funding[2016-1-MS-5] ; Open Funding Project of the State Key Laboratory of Biochemical Engineering[2019KF-02]
WOS关键词	BETA-SHEET ; DESIGN ; FABRICATION ; TRANSITION ; GELATION
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000535246100026
资助机构	National Natural Science Foundation of China ; China-Japan Friendship Hospital Research funding ; Open Funding Project of the State Key Laboratory of Biochemical Engineering
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/40851]
专题	中国科学院过程工程研究所
通讯作者	Li, Jingtao; Bai, Shuo
作者单位	1.China Japan Friendship Hosp, Dept Gastroenterol, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Ren, Peng,Li, Jingtao,Zhao, Luyang,et al. Dipeptide Self-assembled Hydrogels with Shear-Thinning and Instantaneous Self-healing Properties Determined by Peptide Sequences[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12(19):21433-21440.
APA	Ren, Peng.,Li, Jingtao.,Zhao, Luyang.,Wang, Anhe.,Wang, Meiyue.,...&Bai, Shuo.(2020).Dipeptide Self-assembled Hydrogels with Shear-Thinning and Instantaneous Self-healing Properties Determined by Peptide Sequences.ACS APPLIED MATERIALS & INTERFACES,12(19),21433-21440.
MLA	Ren, Peng,et al."Dipeptide Self-assembled Hydrogels with Shear-Thinning and Instantaneous Self-healing Properties Determined by Peptide Sequences".ACS APPLIED MATERIALS & INTERFACES 12.19(2020):21433-21440.