Preparation of hydroxyapatite with high surface area and dispersity templated on calcium carbonate in dipeptide hydrogels

doi:10.1016/j.colsurfa.2020.124740

	Preparation of hydroxyapatite with high surface area and dispersity templated on calcium carbonate in dipeptide hydrogels
	Ma, Yuqi 3; Wang, Anhe 1; Li, Jieling 1; Li, Qi 1; Han, Qingquan 1,4; Chen, Yang 1,4; Wang, Shengtao 1,4; Zheng, Xuefang 3; Cao, Hongyu 2,3; Bai, Shuo 1
刊名	COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
	2020-07-05
卷号	596 页码:7
关键词	Porous CaCO3 Template Hydroxyapatite Dipeptide hydrogel Drug release
ISSN号	0927-7757
DOI	10.1016/j.colsurfa.2020.124740
英文摘要	Hydroxyapatite (HAP) is the main inorganic component of human skeletal tissue such as bone, teeth et al. Because of its excellent biocompatibility, biodegradability and mechanical properties, it is widely applied in the field of medicine, particularly in bone repairing and drug release. However, it is difficult to prepare HAP particles with good dispersity in aqueous solution and high surface area. To solve the issue, porous CaCO3 were taken as a template to prepare hydroxyapatite with good dispersity and high surface area assisted by a dipeptide hydrogel system. Experimental data show that the sequence of dipeptide has a great effect on the dispersity of hydroxyapatite particles, and the obtained hydroxyapatite has a same particle size with the template of CaCO3, and can be dispersed in an aqueous solution very well. Meanwhile porous hydroxyapatite particles have a large surface area benefiting the loading of model drugs, and illustrate enhanced cell internalization efficiency and low cytotoxicity, which can be used as a sustained-release drug carrier.
资助项目	National Natural Science Foundation of China[21774132] ; National Natural Science Foundation of China[21703253] ; National Natural Science Foundation of China[21601025] ; National Natural Science Foundation of China[21571025] ; Project of Young Science and Technology Star of Dalian[2017RQ156]
WOS关键词	TISSUE REGENERATION ; TRANSFORMATION ; FABRICATION ; NANOPARTICLE ; CAPSULES ; FACILE
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000531539800004
资助机构	National Natural Science Foundation of China ; Project of Young Science and Technology Star of Dalian
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/40533]
专题	中国科学院过程工程研究所
通讯作者	Wang, Anhe; Zheng, Xuefang; Cao, Hongyu; Bai, Shuo
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Dalian Univ, Coll Life Sci & Biotechnol, Dalian 116622, Peoples R China 3.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China 4.Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Ma, Yuqi,Wang, Anhe,Li, Jieling,et al. Preparation of hydroxyapatite with high surface area and dispersity templated on calcium carbonate in dipeptide hydrogels[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2020,596:7.
APA	Ma, Yuqi.,Wang, Anhe.,Li, Jieling.,Li, Qi.,Han, Qingquan.,...&Bai, Shuo.(2020).Preparation of hydroxyapatite with high surface area and dispersity templated on calcium carbonate in dipeptide hydrogels.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,596,7.
MLA	Ma, Yuqi,et al."Preparation of hydroxyapatite with high surface area and dispersity templated on calcium carbonate in dipeptide hydrogels".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 596(2020):7.