Self-Assembling Proteins for Design of Anticancer Nanodrugs

doi:10.1002/asia.202000135

	Self-Assembling Proteins for Design of Anticancer Nanodrugs
	Zou, Qianli 1; Chang, Rui 1; Yan, Xuehai 1,2
刊名	CHEMISTRY-AN ASIAN JOURNAL
	2020-03-31
页码	16
关键词	Protein Self-assembly Intermolecular interactions Nanodrugs Cancer therapy
ISSN号	1861-4728
DOI	10.1002/asia.202000135
英文摘要	Inspired by the diverse protein-based structures and materials in organisms, proteins have been expected as promising biological components for constructing nanomaterials toward various applications. In numerous studies protein-based nanomaterials have been constructed with the merits of abundant bioactivity and good biocompatibility. However, self-assembly of proteins as a dominant approach in constructing anticancer nanodrugs has not been reviewed. Here, we provide a comprehensive account of the role of protein self-assembly in fabrication, regulation, and application of anticancer nanodrugs. The supramolecular strategies, building blocks, and molecular interactions of protein self-assembly as well as the properties, functions, and applications of the resulting nanodrugs are discussed. The applications in chemotherapy, radiotherapy, photodynamic therapy, photothermal therapy, gene therapy, and combination therapy are included. Especially, manipulation of molecular interactions for realizing cancer-specific response and cancer theranostics are emphasized. By expounding the impact of molecular interactions on therapeutic activity, rational design of highly efficient protein-based nanodrugs for precision anticancer therapy can be envisioned. Also, the challenges and perspectives in constructing nanodrugs based on protein self-assembly are presented to advance clinical translation of protein-based nanodrugs and next-generation nanomedicine.
资助项目	National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21977095] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; CAS President's International Fellowship Initiative[2018VEA0005] ; Youth Innovation Promotion Association CAS[2019051]
WOS关键词	HUMAN SERUM-ALBUMIN ; DRUG-DELIVERY ; PHOTODYNAMIC THERAPY ; GOLD NANOPARTICLE ; BOUND PACLITAXEL ; CANCER-THERAPY ; THERANOSTICS ; TRANSFERRIN ; LIGAND ; HSA
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000522513000001
资助机构	National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS) ; CAS President's International Fellowship Initiative ; Youth Innovation Promotion Association CAS
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/39905]
专题	中国科学院过程工程研究所
通讯作者	Yan, Xuehai
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zou, Qianli,Chang, Rui,Yan, Xuehai. Self-Assembling Proteins for Design of Anticancer Nanodrugs[J]. CHEMISTRY-AN ASIAN JOURNAL,2020:16.
APA	Zou, Qianli,Chang, Rui,&Yan, Xuehai.(2020).Self-Assembling Proteins for Design of Anticancer Nanodrugs.CHEMISTRY-AN ASIAN JOURNAL,16.
MLA	Zou, Qianli,et al."Self-Assembling Proteins for Design of Anticancer Nanodrugs".CHEMISTRY-AN ASIAN JOURNAL (2020):16.